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Citation
Tags
HERO ID
1291082
Reference Type
Journal Article
Title
Observation of a Commercial Fluorinated Material, the Polyfluoroalkyl Phosphoric Acid Diesters, in Human Sera, Wastewater Treatment Plant Sludge, and Paper Fibers
Author(s)
D'Eon, JC; Crozier, PW; Furdui, VI; Reiner, EJ; Libelo, EL; Mabury, SA
Year
2009
Is Peer Reviewed?
1
Journal
Environmental Science & Technology
ISSN:
0013-936X
EISSN:
1520-5851
Volume
43
Issue
12
Page Numbers
4589-4594
Language
English
PMID
19603681
DOI
10.1021/es900100d
Web of Science Id
WOS:000266968500058
Abstract
Sources of human exposure to perfluorinated carboxylic acids (PFCAs) are not well-characterized. Polyfluoroalkyl phosphoric acids (PAPs) are fluorinated surfactants used in human food contact paper products. PAPs can migrate into food and food simulants, and their bioavailability and biotransformation into PFCAs has been demonstrated using a rat model. To characterize human exposure to PAP materials, we analyzed pooled human sera samples collected in 2004 and 2005 (n = 10) and 2008 (n = 10) from the midwestern United States for the 4:2 through 10:2 PAP diesters (diPAPs). The 2004 and 2005 sera samples contained 4.5 microg/L total diPAPs, with the 6:2 diPAP dominating the congener profile at 1.9 +/- 0.4 microg/L DiPAP concentrations observed in the 2004 and 2005 human sera samples were similar to those of the C8 to C11 PFCAs (0.13 +/- 0.01 to 4.2 +/- 0.3 microg/L) monitored in the same samples. 6:2 diPAP was also consistently observed in the 2008 human sera samples at a mean concentration of 0.63 +/- 0.13 microg/L As diPAPs have been shown to degrade to PFCAs in vivo, our observation of diPAPs in human sera may be a direct connection between the legacy of human PFCA contamination and PAPs commercial applications. Wastewater treatment plant (WWTP) sludge and paper fibers were analyzed for diPAPs as a proxy for human use and potential exposure to diPAPs. DiPAPs were observed in WWTP sludge at concentrations ranging from 47 +/- 22 to 200 +/- 130 ng/g, a range similar to perfluorooctane sulfonic acid (PFOS) (100 +/- 70 ng/g) and greater than the C8 to C11 PFCAs (1.6 +/- 0.6 to 0.17 +/- 0.10 ng/g) observed in the same samples. DiPAPs were observed in paper fiber extracts at concentrations ranging from 34 +/- 30 to 2200 +/- 400 ng/g. The high diPAP concentrations in WWTP sludge suggest PAP materials may be prevalent in our daily lives.
Tags
PFAS
•
6:2/8:2 diPAP
Literature Search
Pubmed
WOS
Screening Results
Excluded/Not on Topic
•
6:2 diPAP
Literature Search
Pubmed
WOS
Screening Results
Excluded/Not on Topic
•
Additional PFAS (formerly XAgency)
Literature Search November 2019
Web of Science
Screened Studies
Supplemental
Sodium bis[2-(perfluorohexyl)ethyl] phosphate
•
Expanded PFAS SEM (formerly PFAS 430)
Litsearch: September 2019
PubMed
Web of Science
Screened Studies
Excluded
Exclude (TIAB)
Perfluorooctane
Sodium bis[2-(perfluorohexyl)ethyl] phosphate
•
^Per- and Polyfluoroalkyl Substances (PFAS)
6:2 diPAP (57677-95-9)
Literature Search
Pubmed
WOS
6:2/8:2 diPAP (943913-15-3)
Literature Search
Pubmed
WOS
•
PFAS 150
Literature Search Update December 2020
PubMed
WOS
Literature Search August 2019
PubMed
Web of Science
Not prioritized for screening
Perfluorooctane
Perfluorooctanesulfonate
Perfluorooctanesulfonic acid
•
PFHxS
•
PFNA
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