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1313235 
Journal Article 
Short-term oral toxicity study of diethyl phthalate in the rat 
Brown, D; Butterworth, KR; Gaunt, IF; Grasso, P; Gangolli, SD 
1978 
Yes 
Food and Cosmetics Toxicology
ISSN: 0015-6264
EISSN: 1878-6049 
16 
5 
415-422 
English 
711065 
WOS:A1978FX15600002 
Groups of 15 male and 15 female rats were given diets containing 0 (control), 0.2, 1.0 or 5.0% diethyl phthalate (DEP) for 16 wk. Consumption of diet containing 5% DEP was associated with a reduction in food intake and in the rate of body weight gain, and similar effects were seen in females given 1% DEP. No statistically significant effects on water intake or on the results of the hematological examinations, serum-enzyme levels, urinary cell-excretion rate, renal concentration tests or histological examination were seen in the treated animals. There were increases at wk 16 in the relative liver weight of females at all treatment levels and of males fed the highest level. There were increases in the absolute and relative weights of stomach and small intestine in rats of both sexes; in the females these were statistically significant at all dietary levels at wk 16. 
IRIS
• Diethyl phthalate (DEP)
     Database searches
          Initial Litsearch
               Toxline
               Web of Science
               Merged reference set
          Jan 2020 update
               PubMed
               Web of Science
     Primary source of health effects
          Animal toxicology studies
               Female Repro
               Kidney
               Liver
               Male Repro