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1313609 
Journal Article 
Formaldehyde, aspartame, and migraines: a possible connection 
Jacob, SE; Stechschulte, S 
2008 
Yes 
Dermatitis
ISSN: 1710-3568 
19 
3 
E10-E11 
English 
18627677 
Aspartame is a widely used artificial sweetener that has been linked to pediatric and adolescent migraines. Upon ingestion, aspartame is broken, converted, and oxidized into formaldehyde in various tissues. We present the first case series of aspartame-associated migraines related to clinically relevant positive reactions to formaldehyde on patch testing. 
IRIS
• Formaldehyde [archived]
     Immune Section
          Exclude - Contact dermatitis, patch testing studies
     Inflammation/Reactive Oxygen Species
          PubMed
          Screened by Title/Abstract
               Patch testing and/or Contact Allergy Dermatitis (for possible further review)
     Retroactive RIS import
          2013
               HERO Formaldehyde Immune Section 20Mar2013
          2014
               HERO_Formaldehyde_InflammationReactiveOxygenSpecies_pid_31_uid_5713Sorting091214
               HERO_Formaldehyde_InflammationReactiveOxygenSpecies_pid_31_uid_5713
                    Screened (Title/Abstract)
                         Patch testing and/or Contact Allergy/Dermatitis (for possible further review)
               Immune_HERO_allyr
• IRIS Formaldehyde (Inhalation) [Final 2024]
     Literature Indexing
          PubMed
     Literature Identification
          Immune-Mediated Conditions in Humans, Including Asthma and Allergy
               Excluded
          Inflammation and Immune-Related Mechanistic Studies
               Excluded