Jump to main content
US EPA
United States Environmental Protection Agency
Search
Search
Main menu
Environmental Topics
Laws & Regulations
About EPA
Health & Environmental Research Online (HERO)
Contact Us
Print
Feedback
Export to File
Search:
This record has one attached file:
Add More Files
Attach File(s):
Display Name for File*:
Save
Citation
Tags
HERO ID
1325667
Reference Type
Journal Article
Title
A novel ion selective PVC membrane electrode for determination of propranolol in pharmaceutical formulation
Author(s)
Aboul-Enein, HY; Sun, XX
Year
2000
Is Peer Reviewed?
Yes
Journal
Analusis
ISSN:
0365-4877
Volume
28
Issue
9
Page Numbers
855-858
Language
English
DOI
10.1051/analusis:2000156
Web of Science Id
WOS:000167545500017
Abstract
A novel ion selective PVC membrane electrode for determination of propranolol is developed. Silicotungstic acid is used as the counter ion and diisononyl phthalate (DNP) used as the plastizer. The electrode exhibits excellent potential response properties, showing a Nernstian response in the concentration of 3.0 x 10(-6) similar to 2.6 x 10(-2) M with the slope of 54.7 mV per decade, shorter conditioning time (similar to 3 h), fast response time (40 s), a lower limit of detection (1.0 x 10(-7) M). The electrode is successfully used for the analysis of propranolol in pharmaceutical formulation with the recoveries of 99.2 similar to 102.6 %, by using a direct potentiometric method and which does not require tedious sample preparation.
Keywords
propranolol; ion-selective electrode; potentiometry; analysis of drugs; pharmaceutical analysis; chemical sensors
Tags
IRIS
•
Diisononyl Phthalate (DINP)
Literature Search
LitSearch May 2013
Web of Science
Excluded: No Primary Data on Health Effects
Manufacture/use
Home
Learn about HERO
Using HERO
Search HERO
Projects in HERO
Risk Assessment
Transparency & Integrity