US EPA

1332522 

Journal Article 

In vitro assessment of thyroid hormone disrupting activities in drinking water sources along the Yangtze River 

Hu, X; Shi, W; Zhang, F; Cao, F; Hu, G; Hao, Y; Wei, S; Wang, X; Yu, H 

2013 

Yes 

Environmental Pollution
ISSN: 0269-7491
EISSN: 1873-6424 

Environ Pollut. 2013, Feb; 173:210-5. [Environmental pollution (Barking, Essex : 1987)] 

173 

210-215 

English 

23202652 

10.1016/j.envpol.2012.10.022 

WOS:000313845500028 

https://search.proquest.com/docview/1663576445?accountid=171501
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The thyroid hormone disrupting activities of drinking water sources from the lower reaches of Yangtze River were examined using a reporter gene assay based on African green monkey kidney fibroblast (CV-1) cells. None of the eleven tested samples showed thyroid receptor (TR) agonist activity. Nine water samples exhibited TR antagonist activities with the equivalents referring to Di-n-butyl phthalate (DNBP) (TR antagonist activity equivalents, ATR-EQ(50)s) ranging from 6.92 × 10(1) to 2.85 × 10(2) μg DNBP/L. The ATR-EQ(50)s and TR antagonist equivalent ranges (ATR-EQ(30-80) ranges) for TR antagonist activities indicated that the water sample from site WX-8 posed the greatest health risks. The ATR-EQ(80)s of the water samples ranging from 1.56 × 10(3) to 6.14 × 10(3) μg DNBP/L were higher than the NOEC of DNBP. The results from instrumental analysis showed that DNBP might be responsible for the TR antagonist activities in these water samples. Water sources along Yangtze River had thyroid hormone disrupting potential. 

Reporter gene assay; Drinking water source; Thyroid hormone disrupting activity; Thyroid receptor antagonist equivalent; Thyroid receptor antagonist equivalent range