US EPA

1332669 

Journal Article 

The embryo-fetal toxicity and teratogenic potential of ammonium perfluorooctanoate (APFO) in the rat 

Staples, RE; Burgess, BA; Kerns, WD 

1984 

Yes 

Fundamental and Applied Toxicology
ISSN: 0272-0590
EISSN: 1095-6832 

ETICBACK/35299 

4 

3 Pt 1 

429-440 

English 

6745532 

10.1093/toxsci/4.3part1.429 

WOS:A1984SZ56600015 

http://dx.doi.org/10.1093/toxsci/4.3part1.429
Exit
 

Ammonium perfluorooctanoate (APFO, greater than 95% pure) was administered to Sprague-Dawley rats from Days 6 through 15 of gestation by inhalation as a dust (whole body exposure) for 6 hr/day at 0, 0.1, 1, 10, and 25 mg/m3, or by gavage at 100 mg/kg body wt/day in corn oil. Maternal deaths occurred in the groups given the highest level of APFO by each route and overt toxicity was evident among the surviving dams of these groups and among those of the 10-mg/m3 group. The fetuses were examined for external, visceral, and skeletal alterations and for APFO-related macroscopic and microscopic alterations of the eyes. In the postpartum period, pups from additional control and experimental dams were examined externally and ophthalmoscopically, and the usual fertility and viability indices were calculated. A teratogenic response was not demonstrated. Toxic effects on the conceptus were noted only in the groups given the highest level of APFO by each route. Hence, APFO was not demonstrated to represent a unique hazard to the conceptus of the rat.