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HERO ID
1333776
Reference Type
Journal Article
Title
Maternal in utero exposure to the endocrine disruptor di-(2-ethylhexyl) phthalate affects the blood pressure of adult male offspring
Author(s)
Martinez-Arguelles, DB; Mcintosh, M; Rohlicek, CV; Culty, M; Zirkin, BR; Papadopoulos, V
Year
2013
Is Peer Reviewed?
1
Journal
Toxicology and Applied Pharmacology
ISSN:
0041-008X
EISSN:
1096-0333
Book Title
Toxicol Appl Pharmacol.
Volume
266
Issue
1
Page Numbers
95-100
Language
English
PMID
23142467
DOI
10.1016/j.taap.2012.10.027
Web of Science Id
WOS:000313474200011
URL
https://search.proquest.com/docview/1240895416?accountid=171501
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Abstract
Di-(2-ethylhexyl) phthalate (DEHP) is used industrially to add flexibility to polyvinyl chloride (PVC) polymers and is ubiquitously found in the environment, with evidence of prenatal, perinatal and early infant exposure in humans. In utero exposure to DEHP decreases circulating testosterone levels in the adult rat. In addition, DEHP reduces the expression of the angiotensin II receptors in the adrenal gland, resulting in decreased circulating aldosterone levels. The latter may have important effects on water and electrolyte balance as well as systemic arterial blood pressure. Therefore, we determined the effects of in utero exposure to DEHP on systemic arterial blood pressure in the young (2month-old) and older (6.5month-old) adult rats. Sprague-Dawley pregnant dams were exposed from gestational day 14 until birth to 300mg DEHP/kg/day. Blood pressure, heart rate, and activity data were collected using an intra-aortal transmitter in the male offspring at postnatal day (PND) 60 and PND200. A low (0.01%) and high-salt (8%) diet was used to challenge the animals at PND200. In utero exposure to DEHP resulted in reduced activity at PND60. At PND200, systolic and diastolic systemic arterial pressures as well as activity were reduced in response to DEHP exposure. This is the first evidence showing that in utero exposure to DEHP has cardiovascular and behavioral effects in the adult male offspring.
Keywords
Adrenal gland; Phthalate; Aldosterone; Systolic pressure; Activity
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Phthalates – Targeted Search for Epidemiological Studies
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