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Citation
Tags
HERO ID
1340047
Reference Type
Journal Article
Title
Local inflammation and human papillomavirus status of head and neck cancers
Author(s)
Tezal, M; Scannapieco, FA; Wactawski-Wende, J; Hyland, A; Marshall, JR; Rigual, NR; Stoler, DL
Year
2012
Is Peer Reviewed?
Yes
Journal
Archives of Otolaryngology - Head and Neck Surgery
ISSN:
0886-4470
EISSN:
1538-361X
Volume
138
Issue
7
Page Numbers
669-675
Language
English
PMID
22710409
DOI
10.1001/archoto.2012.873
URL
http://archotol.jamanetwork.com/article.aspx?doi=10.1001/archoto.2012.873
Exit
Abstract
OBJECTIVE:
To determine whether periodontitis is associated with human papillomavirus (HPV) status of head and neck squamous cell carcinoma (HNSCC).
DESIGN AND SETTING:
Hospital-based case-control study in a comprehensive cancer center.
PATIENTS:
Evaluation included all patients diagnosed with incident primary squamous cell carcinoma of the oral cavity, oropharynx, and larynx between 1999 and 2007 for whom tissue samples and dental records were available (N = 124). Patients younger than 21 years and those with a history of cancer were excluded. Periodontitis history was assessed by alveolar bone loss in millimeters from panoramic radiographs by one examiner blinded to cancer status.
MAIN OUTCOME MEASURE:
The presence of HPV-16 DNA in paraffin-embedded tumor samples was identified by polymerase chain reaction.
RESULTS:
The prevalence of HPV-positive HNSCC was 50 of 124 patients (40.3%). A higher proportion of oropharyngeal cancers were HPV-positive (32 of 49 [65.3%]) compared with oral cavity (9 of 31 [29.0%]) and laryngeal (9 of 44 [20.5%]) cancers. Each millimeter of alveolar bone loss was associated with 2.6 times increased odds (odds ratio [OR], 2.61; 95% CI, 1.58-4.30) of HPV-positive tumor status after adjustment for age at diagnosis, sex, and smoking status. The strength of the association was greater among patients with oropharyngeal SCC (OR, 11.70; 95% CI, 2.09-65.53) compared with those with oral cavity SCC (OR, 2.32; 95% CI, 0.65-8.27) and laryngeal SCC (OR, 3.89; 95% CI, 0.95-15.99).
CONCLUSIONS:
A history of chronic inflammatory disease in the oral cavity may be associated with tumor HPV status in patients with HNSCC. This association seems to be stronger among patients with oropharyngeal cancer compared with those who have oral cavity or laryngeal SCC.
Tags
IRIS
•
Arsenic Hazard ID
1. Initial Lit Search
PubMed
4. Considered through Oct 2015
6. Cluster Filter through Oct 2015
•
Arsenic (Inorganic)
1. Literature
PubMed
4. Adverse Outcome Pathways/Networks Screening
Excluded/Not relevant
Electronic discard
•
Arsenic MOA
2. Electronic Discard
1. MOA Literature Screening
MOA Cluster
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