Jump to main content
US EPA
United States Environmental Protection Agency
Search
Search
Main menu
Environmental Topics
Laws & Regulations
About EPA
Health & Environmental Research Online (HERO)
Contact Us
Print
Feedback
Export to File
Search:
This record has one attached file:
Add More Files
Attach File(s):
Display Name for File*:
Save
Citation
Tags
HERO ID
1341552
Reference Type
Journal Article
Subtype
Review
Title
Cryptorchidism and endocrine disrupting chemicals
Author(s)
Virtanen, HE; Adamsson, A
Year
2012
Is Peer Reviewed?
1
Journal
Molecular and Cellular Endocrinology
ISSN:
0303-7207
EISSN:
1872-8057
Volume
355
Issue
2
Page Numbers
208-220
Language
English
PMID
22127307
DOI
10.1016/j.mce.2011.11.015
Web of Science Id
WOS:000303642400004
Abstract
Prospective clinical studies have suggested that the rate of congenital cryptorchidism has increased since the 1950s. It has been hypothesized that this may be related to environmental factors. Testicular descent occurs in two phases controlled by Leydig cell-derived hormones insulin-like peptide 3 (INSL3) and testosterone. Disorders in fetal androgen production/action or suppression of Insl3 are mechanisms causing cryptorchidism in rodents. In humans, prenatal exposure to potent estrogen diethylstilbestrol (DES) has been associated with increased risk of cryptorchidism. In addition, epidemiological studies have suggested that exposure to pesticides may also be associated with cryptorchidism. Some case-control studies analyzing environmental chemical levels in maternal breast milk samples have reported associations between cryptorchidism and chemical levels. Furthermore, it has been suggested that exposure levels of some chemicals may be associated with infant reproductive hormone levels.
Keywords
Cryptorchidism; Testis; Endocrine disrupting chemical
Tags
IRIS
•
Dibutyl Phthalate (DBP)
Database Searches
Web of Science
LitSearch Nov 2012
WOS
Merged reference set
LitSearch Dec 2012 - June 2013
Web of Science
Secondary Literature
Reviews and Editorials
•
Diisononyl Phthalate (DINP)
Additional Search Strategies
March 2017 Search strategy results
Secondary Literature
Reviews/editorials
•
Phthalates – Targeted Search for Epidemiological Studies
Source – all searches
WOS
Excluded
Source – no date limit through June 2013 (Private)
WOS
Home
Learn about HERO
Using HERO
Search HERO
Projects in HERO
Risk Assessment
Transparency & Integrity