US EPA

1350453 

Journal Article 

Combined administration of selenium and meso-2, 3-dimercaptosuccinic acid on arsenic mobilization and tissue oxidative stress in chronic arsenic-exposed male rats 

Modi, M; Mittal, M; Flora, SJS 

2007 

Yes 

Indian Journal of Pharmacology
ISSN: 0253-7613
EISSN: 19983751 

39 

2 

107-114 

WOS:000207065600009 

Objective : The present study describes the effect of
selenium either alone or in combination with meso-2, 3-dimercaptosuccinic acid (DMSA) against
chronic arsenic poisoning in rats. Materials and Methods : Male Wistar rats were exposed to 100
ppm sodium arsenite in drinking water for eight months and treated thereafter with DMSA (0.3
mmol/kg orally) either individually or in combination with selenium (Se, 6.3 or 12.6 mol/kg,
intraperitoneally) once daily for five days. The effects of these treatments in influencing the
arsenic (As)-induced changes in heme synthesis, hepatic, renal or brain oxidative stress were
evaluated along with the As concentration in blood and soft tissues. Results : Exposure to As
significantly altered biochemical parameters related to the heme synthesis pathway, blood and
organ (liver, kidney and brain) oxidative stress while increasing body As burden in animals.
Treatment with DMSA alone significantly reduced the adverse effects related to most of these
biochemical parameters as well as the As concentration in blood and tissues. On the other hand,
co-administration of Se with DMSA had only limited additional beneficial effects (particularly
tissue oxidative stress) over the individual effect of DMSA. Conclusion : The above results
suggest that Se administration during chelation affected by other agents had some beneficial
effects on oxidative stress with no major additional beneficial effect on arsenic depletion. 

Arsenic toxicity; chelating agent; oxidative stress; rats; selenium; combination therapy