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1390685 
Journal Article 
Squamous epithelioma probably due to tar ointment in a case with psoriasis 
Alexander, JOD; Macrosson, KI 
1954 
Yes 
British Medical Journal
ISSN: 0007-1447 
2 
4896 
1089 
English 
13199389 
A case of squamous epithelioma arising on a patch of psoriasis in a 31 year old male was investigated. The patient presented with a 2 centimeter lump over the head of the right fibula. The lesion was raised 3 to 4 millimeters above the skin surface; the edge was firm and rolled, and the center showed slight ulceration without discharge. There was also a diffuse discoid psoriasis and a marked tar acne with one or two tar mollusca. No history of arsenic administration was found, and the only agent applied to the skin that might have been carcinogenic was an ointment containing salicylic-acid (69727), oleated-mercury (1191806), coal-tar, and an emulsifying base. Lesions appeared 14 days after initiation of tar ointment application. The patient used this ointment for 3 months before seeking medical advise. The epitheliomatous lesion was excised, and the diagnosis of squamous carcinoma was confirmed histologically. The author concludes that the continued insult to the skin of the tar ointment is the essential factor in the production of malignant change. 
DCN-115797; Skin disorders; Skin lesions; Skin cancer; Skin tumors; Carcinogens; Malignancy; Malignant neoplasms; Case studies; Skin diseases