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HERO ID
1407331
Reference Type
Journal Article
Title
Effect of adrenalectomy on chlordecone potentiation of carbontetrachloride hepatotoxicity
Author(s)
Agarwal, AK; Mehendale, HM
Year
1983
Is Peer Reviewed?
Yes
Journal
Fundamental and Applied Toxicology
ISSN:
0272-0590
EISSN:
1095-6832
Report Number
NIOSH/00151953
Volume
3
Issue
6
Page Numbers
507-511
Language
English
PMID
6198234
Web of Science Id
WOS:A1983RX77700004
Abstract
The propensity of chlordecone (CD) to potentiate CCl4 hepatotoxicity in rats of either sex has been well documented. The objective of the present study was to investigate the hepatotoxic effects of CD-CCl4 interaction in adrenalectomized rats. Adrenalectomized rats were maintained on 0 or 10 ppm CD and on day 15 they received a single ip injection of 25 microL CCl4/kg. Hepatotoxicity was assessed by hepatofunctional, biochemical and histopathological parameters, 24 hrs after CCl4 challenge. CCl4-induced hepatobiliary dysfunction and elevation of serum enzymes (GPT, GOT, ICD and OCT) were evident. Hepatic dysfunction was most severe in adrenalectomized rats receiving CD-CCl4 combination treatment. Histopathology of liver exhibited extensive fatty infiltration in the entire lobular structure accompanied by some necrosis. These data indicate that the capacity of CD to potentiate CCl4 hepatotoxicity is unaffected in adrenalectomized rats.
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