Mechanism of bronchoconstriction during inhalation of sulfur dioxide | Health & Environmental Research Online (HERO)

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Citation
Tags

HERO ID

14846

Reference Type

Journal Article

Title

Mechanism of bronchoconstriction during inhalation of sulfur dioxide

Author(s)

Nadel, JA; Salem, H; Tamplin, B; Tokiwa, Y

Year

1965

Is Peer Reviewed?

Yes

Journal

Journal of Applied Physiology (1985)
ISSN: 8750-7587
EISSN: 1522-1601

Volume

Issue

Page Numbers

164-167

Language

English

PMID

14257550

URL

http://jap.physiology.org/content/20/1/164
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Abstract

Inhalation of SO2 (4–6 ppm) for 10 min decreased airway conductance (increased airway resistance) in seven healthy subjects. Subcutaneous injection of atropine prevented this effect. In anesthetized, paralyzed, artifically ventilated cats, SO2 increased pulmonary resistance, whether delivered to the upper or to the lower airways. This was prevented by complete cold block of the cervical vagosympathetic nerves or by injecting atropine intravenously before the SO2 was inhaled. These results establish the reflex nature of bronchoconstriction during inhalation of SO2.