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1510358 
Journal Article 
Prenatal exposure to polychlorinated biphenyls and dioxins from the maternal diet may be associated with immunosuppressive effects that persist into early childhood 
Stølevik, SB; Nygaard, UC; Namork, E; Haugen, M; Meltzer, HM; Alexander, J; Knutsen, HK; Aaberge, I; Vainio, K; van Loveren, H; Løvik, M; Granum, B 
2013 
Yes 
Food and Chemical Toxicology
ISSN: 0278-6915
EISSN: 1873-6351 
51 
165-172 
English 
We investigated whether prenatal exposure from the maternal diet to the toxicants polychlorinated biphenyls (PCBs) and dioxins is associated with the development of immune-related diseases in childhood. Children participating in BraMat, a sub-cohort of the Norwegian Mother and Child Cohort Study (MoBa), were followed in the three first years of life using annual questionnaires (0-3years; n=162, 2-3years; n=180), and blood parameters were examined at three years of age (n=114). The maternal intake of the toxicants was calculated using a validated food frequency questionnaire from MoBa. Maternal exposure to PCBs and dioxins was found to be associated with an increased risk of wheeze and more frequent upper respiratory tract infections. Furthermore, maternal exposure to PCBs and dioxins was found to be associated with reduced antibody response to a measles vaccine. No associations were found between prenatal exposure and immunophenotype data, allergic sensitization and vaccine-induced antibody responses other than measles. Our results suggest that prenatal dietary exposure to PCBs and dioxins may increase the risk of wheeze and the susceptibility to infectious diseases in early childhood. 
Polychlorinated biphenyls; Dioxins; Prenatal; Diet; Immunotoxicity 
IRIS
• PCBs
     Hazard ID: Epidemiological evidence
     Mechanistic
     Litsearches
          Remaining
          LitSearch August 2015
               Pubmed
               Toxline
               WoS
     Cited (Nov 2012)
• PCBs Epi Hazard ID
     Health Effects
          Immunological