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Citation
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HERO ID
1514222
Reference Type
Journal Article
Title
Occupational trichloroethylene exposure and cervical pathology: A case-control study
Author(s)
Charbotel, B; Massardier-Pilonchery, A; Fort, E; Dananché, B; Févotte, J; Confavreux-Romestaing, C; Bergeret, A
Year
2013
Is Peer Reviewed?
Yes
Journal
Annals of Occupational Hygiene
ISSN:
0003-4878
EISSN:
1475-3162
Volume
57
Issue
3
Page Numbers
407-416
Language
English
PMID
23091111
DOI
10.1093/annhyg/mes075
Web of Science Id
WOS:000316270000013
Abstract
OBJECTIVES:
Trichloroethylene (TCE) is suspected of association with elevated risk of cervical cancer. A case-control study was performed in a geographical area in which occupational TCE exposure is high. The study objective was to analyze the correlation between occupational TCE exposure and cervical cancer (including precancerous conditions).
METHODS:
Case and control subjects were recruited by gynecologists. General and occupational data were collected by telephonic interviews. An industrial hygienist assessed occupational TCE exposure on a task-exposure matrix. Analysis focused on occupational TCE exposure at various levels and on cumulative dose. Multivariate analysis was performed to take account of the various risk factors.
RESULTS:
In total, 67 case and 67 age-matched control subjects were included. Mean age was 36 years in both groups. Five of the possible general risk factors correlated significantly with cervical dysplasia or cancer: number of partners, history of genital or anal wart, interval between first period and first sexual relation, parity, and body mass index, the last three showing inverse correlation. Elevated risk was found in women who had had jobs as manual workers according to the PCS French classification (professions and socioprofessional categories), and production and related workers according to ISCO classification (International Standard Classification of Occupations), with odds ratios (ORs), adjusted on general and medical risk factors, of 7.68 [95% confidence interval (CI): 1.39-42.54] and 7.48 (1.30-43.24), respectively, among skilled service sector workers; the adjusted OR was close to significance, at 4.67 (95% CI: 0.92-23.67). No occupational sectors were significantly associated with elevated risk. In all, 17 (25.4%) case and 15 (22.4%) control subjects were exposed to TCE: raw OR = 1.17 (95% CI: 0.54-2.52), adjusted OR = 1.51 (95% CI: 0.42-5.41). There was no significant correlation between cumulative dose and exposure time.
CONCLUSIONS:
The study found no significantly increased risk of cervical dysplasia or cancer associated with occupational TCE exposure.
Keywords
cervical cancer; cervix dysplasia; chlorinated hydrocarbons; occupational diseases; trichloroethylene
Tags
•
Trichloroethylene (TCE) (Final, 2011)
OPPT REs
•
OPPT_Trichloroethylene (TCE)_C. Engineering
Total – title/abstract screening
On topic
Peer review
Primary source
•
OPPT_Trichloroethylene (TCE)_D. Exposure
Total – title/abstract screening
Off topic
•
OPPT_Trichloroethylene (TCE)_E. Fate
Total – title/abstract screening
Off topic
•
OPPT_Trichloroethylene (TCE)_F. Human Health
Total – title/abstract screening
On topic
Peer review
Primary source
On topic - additional tags for titles/abstracts
Human hazard ID
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