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HERO ID
1518997
Reference Type
Journal Article
Title
The association of ambient air pollution and traffic exposures with selected congenital anomalies in the San Joaquin Valley of California
Author(s)
Padula, AM; Tager, IB; Carmichael, SL; Hammond, SK; Lurmann, F; Shaw, GM
Year
2013
Is Peer Reviewed?
Yes
Journal
American Journal of Epidemiology
ISSN:
0002-9262
EISSN:
1476-6256
Volume
177
Issue
10
Page Numbers
1074-1085
Language
English
PMID
23538941
DOI
10.1093/aje/kws367
Web of Science Id
WOS:000318801200006
URL
https://academic.oup.com/aje/article-lookup/doi/10.1093/aje/kws367
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Abstract
Congenital anomalies are a leading cause of infant mortality and are important contributors to subsequent morbidity. Studies suggest associations between environmental contaminants and some anomalies, although evidence is limited. We aimed to investigate whether ambient air pollutant and traffic exposures in early gestation contribute to the risk of selected congenital anomalies in the San Joaquin Valley of California, 1997-2006. Seven exposures and 5 outcomes were included for a total of 35 investigated associations. We observed increased odds of neural tube defects when comparing the highest with the lowest quartile of exposure for several pollutants after adjusting for maternal race/ethnicity, education, and multivitamin use. The adjusted odds ratio for neural tube defects among those with the highest carbon monoxide exposure was 1.9 (95% confidence interval: 1.1, 3.2) compared with those with the lowest exposure, and there was a monotonic exposure-response across quartiles. The highest quartile of nitrogen oxide exposure was associated with neural tube defects (adjusted odds ratio = 1.8, 95% confidence interval: 1.1, 2.8). The adjusted odds ratio for the highest quartile of nitrogen dioxide exposure was 1.7 (95% confidence interval: 1.1, 2.7). Ozone was associated with decreased odds of neural tube defects and increased odds of gastroschisis among mothers aged ≥20 years. Our results extend the limited body of evidence regarding air pollution exposure and adverse birth outcomes.
Keywords
air pollution; birth outcomes; congenital anomalies; traffic
Tags
NAAQS
•
ISA-CO (2010 Final Project Page)
•
ISA-NOx (2016)
Considered
Health Effects
Cited
1st Draft
Epidemiology
2nd Draft
Final
Final Cited
•
ISA-Ozone (2013 Final Project Page)
•
ISA-Ozone (2020 Final Project Page)
Literature Search Results
Literature Search - Included
Keyword Search
Topic Classified Epidemiology
Title-Abstract Screening (SWIFT-AS) - Included
Title-Abstract Screening (SWIFT-AS) - Included
Full-Text Screening Included
Full-Text Screening Included
Included in ISA First Draft
Appendix 7
Included in ISA Final Draft
Appendix 7
•
ISA-PM (2009 Final Project Page)
•
ISA-PM (2019)
Peer Input Draft
Chapter 6
1st Draft
Chapter 9
Final ISA
Chapter 9
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