Jump to main content
US EPA
United States Environmental Protection Agency
Search
Search
Main menu
Environmental Topics
Laws & Regulations
About EPA
Health & Environmental Research Online (HERO)
Contact Us
Print
Feedback
Export to File
Search:
This record has one attached file:
Add More Files
Attach File(s):
Display Name for File*:
Save
Citation
Tags
HERO ID
1519068
Reference Type
Journal Article
Title
Fish micronucleus assay to assess genotoxic potential of arsenic at its guideline exposure in aquatic environment
Author(s)
Kumar, A; Kesari, VP; Khan, PK
Year
2013
Is Peer Reviewed?
Yes
Journal
BioMetals
ISSN:
0966-0844
EISSN:
1572-8773
Volume
26
Issue
2
Page Numbers
337-346
Language
English
PMID
23494554
DOI
10.1007/s10534-013-9620-8
Web of Science Id
WOS:000319802100012
URL
http://link.springer.com/10.1007/s10534-013-9620-8
Exit
Abstract
The exposure to arsenic, a potential genotoxic carcinogen in humans, via drinking water is a serious worldwide health hazard. The arsenic content of 10 μg L(-1) in drinking water, however, has been established as its guideline standard (maximum contaminant limit) that has been estimated to pose minimum risk to cancer. Since micronucleus induction in the erythrocytes of fish is a sensitive indicator of genotoxic agents in water, the piscine micronucleus assay was used in the present experiment to assess the genotoxic potential of arsenic at its various exposure levels including the guideline value for drinking water. The experiments were conducted in two different species of fishes, the pond murrel (Channa punctatus) and the goldfish (Carassius auratus). Significant increases in the frequency of micronucleated erythrocytes were documented in a dose-dependent manner in both Channa and Carassius. The fishes, however, exhibited variations in inter-specific sensitivity to micronucleus induction following arsenic exposure. The exposure level of arsenic at its guideline value for drinking water, therefore, exhibited marked genotoxicity in fishes.
Keywords
Arsenic; Genotoxicity; Fish; Guideline value; Micronucleus
Tags
•
Arsenic Hazard ID
ToxNet
PubMed
Considered New
PubMed
Considered New
ToxNet
Excluded
Toxnet Duplicates
ToxNet
Excluded
Toxnet Duplicates
WOS
ToxNet
Excluded
Toxnet Duplicates
ToxNet
Excluded
Toxnet Duplicates
ToxNet
Excluded
Toxnet Duplicates
WOS
ToxNet
Excluded
Toxnet Duplicates
ToxNet
Excluded
Toxnet Duplicates
ToxNet
Excluded
Toxnet Duplicates
2. Lit Search Updates through Oct 2015
PubMed
WOS
ToxNet
Considered
7. Other Studies through Oct 2015
Ecology
•
Arsenic (Inorganic)
1. Literature
Lit search updates through Oct 2015
3. Hazard ID Screening
Other potentially supporting studies
•
Arsenic Susceptibility
Life Stages Citation Mapping
15%-20%
Home
Learn about HERO
Using HERO
Search HERO
Projects in HERO
Risk Assessment
Transparency & Integrity