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Citation
Tags
HERO ID
1519093
Reference Type
Journal Article
Title
Protective role of AQP3 in UVA-induced NHSFs apoptosis via Bcl2 up-regulation
Author(s)
Xie, H; Liu, F; Liu, L; Dan, J; Luo, Y; Yi, Y; Chen, X; Li, J
Year
2013
Is Peer Reviewed?
Yes
Journal
Archives of Dermatological Research
ISSN:
0340-3696
EISSN:
1432-069X
Volume
305
Issue
5
Page Numbers
397-406
Language
English
PMID
23463292
DOI
10.1007/s00403-013-1324-y
Web of Science Id
WOS:000320814500005
Abstract
Aquaporin-3 (AQP3), a water/glycerol-transporting protein that facilitates water, urea, and glycerol transport, can inhibit arsenite-induced apoptosis by up-regulating Bcl-2. However, whether it has a protective role in ultraviolet A (UVA)-induced apoptosis in normal human skin fibroblasts is not known. In this study, we demonstrate that mild UVA treatment fails to induce oxidative cell stress and apoptosis in normal human skin fibroblasts (NHSFs) overexpressing AQP3. After severe UVA irradiation, there was an increase in oxidative cell stress and apoptosis when AQP3 levels decreased. We also found that silencing AQP3 sensitized NHSFs to low-dose UVA. Overexpressing AQP3 was protective against high-dose UVA-induced oxidative stress and apoptosis. Besides, we observed that Bcl-2 may be involved in UVA-induced apoptosis. Our findings suggested that the water/glycerol-transporting protein AQP3 plays a role in resistance to UVA-induced apoptosis.
Keywords
Aquaporin 3; Apoptosis; UVA; Human skin fibroblasts; Bcl-2
Tags
IRIS
•
Arsenic Hazard ID
PubMed
Considered New
PubMed
Considered New
PubMed
Considered New
WOS
Considered New
2. Lit Search Updates through Oct 2015
PubMed
WOS
Considered
7. Other Studies through Oct 2015
Non-Arsenic
•
Arsenic (Inorganic)
1. Literature
Lit search updates through Oct 2015
3. Hazard ID Screening
Other potentially supporting studies
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