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1519093 
Journal Article 
Protective role of AQP3 in UVA-induced NHSFs apoptosis via Bcl2 up-regulation 
Xie, H; Liu, F; Liu, L; Dan, J; Luo, Y; Yi, Y; Chen, X; Li, J 
In Press 
Yes 
Archives of Dermatological Research
ISSN: 0340-3696
EISSN: 1432-069X 
305 
397-406 
English 
Aquaporin-3 (AQP3), a water/glycerol-transporting protein that facilitates water, urea, and glycerol transport, can inhibit arsenite-induced apoptosis by up-regulating Bcl-2. However, whether it has a protective role in ultraviolet A (UVA)-induced apoptosis in normal human skin fibroblasts is not known. In this study, we demonstrate that mild UVA treatment fails to induce oxidative cell stress and apoptosis in normal human skin fibroblasts (NHSFs) overexpressing AQP3. After severe UVA irradiation, there was an increase in oxidative cell stress and apoptosis when AQP3 levels decreased. We also found that silencing AQP3 sensitized NHSFs to low-dose UVA. Overexpressing AQP3 was protective against high-dose UVA-induced oxidative stress and apoptosis. Besides, we observed that Bcl-2 may be involved in UVA-induced apoptosis. Our findings suggested that the water/glycerol-transporting protein AQP3 plays a role in resistance to UVA-induced apoptosis. 
Aquaporin 3; Apoptosis; UVA; Human skin fibroblasts; Bcl-2 
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