US EPA

1598053 

Journal Article 

Probabilistic assessment of the cumulative dietary exposure of the population of Denmark to endocrine disrupting pesticides 

Jensen, BH; Petersen, A; Christiansen, S; Boberg, J; Axelstad, M; Herrmann, SS; Poulsen, ME; Hass, U 

2013 

Yes 

Food and Chemical Toxicology
ISSN: 0278-6915
EISSN: 1873-6351 

55 

113-120 

English 

23333574 

10.1016/j.fct.2013.01.002 

WOS:000317536900015 

The four pesticides epoxiconazole, prochloraz, procymidone and tebuconazole, are commonly used pesticides, all suspected of acting as endocrine disrupters. In the present study, we assessed the acute cumulative dietary exposure to the women of child bearing age and the general population of Denmark to these pesticides from the intake of fruit and vegetables. The assessment was carried out using the probabilistic approach combined with the relative potency factor (RPF) approach. Residue data for prochloraz, procymidone, and tebuconazole were obtained from the Danish monitoring programme 2006-2009, while residue data for epoxiconazole were obtained from the Swedish monitoring programme carried out in the period 2007-2009. Food consumption data were obtained from the Danish nationwide dietary survey conducted in 2000-2002. Relative potency factors for the four pesticides were obtained from rat studies. Prochloraz was used as the index compound. All four pesticides increased nipple retention in male offspring, and epoxiconazole, prochloraz, and tebuconazole also increased the gestation period in pregnant rat dams. For women of childbearing age, the high-end cumulative exposure (99.9th percentile) was calculated to 9% of the Adjusted Reference Value (ARV) for the effect on nipple retention and to 1% of the ARV for the effect on increased gestation period. (C) 2013 Elsevier Ltd. All rights reserved. 

Cumulative dietary exposure; Probabilistic modelling; Endocrine disrupting pesticides; Relative potency factor