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HERO ID
1616835
Reference Type
Journal Article
Title
Comedogenicity in rabbit: some cosmetic ingredients/vehicles
Author(s)
Nguyen, SH; Dang, TP; Maibach, HI
Year
2007
Is Peer Reviewed?
Yes
Journal
Cutaneous and Ocular Toxicology
ISSN:
1556-9527
EISSN:
1556-9535
Volume
26
Issue
4
Page Numbers
287-292
Language
English
PMID
18058303
DOI
10.1080/15569520701555383
Web of Science Id
WOS:000251751000002
Abstract
The rabbit external ear canal was used to define which chemicals caused comedone formation on topical application. Some of the tested ingredients are currently used in topically applied formulations. Certain raw materials have been shown to produce follicular hyperkeratosis in the rabbit ear assay. This study quantifies comedogenic potential of cosmetic materials, including: isopropyl palmitate, isopropyl myristate, butyl stearate, isopropyl isostearate, decyl oleate, isostearyl neopentanoate, isocetyl stearate, myristle myristate, cocoa butter, cetyl alcohol, paraffin, stearyl alcohol sodium lauryl sulfate (SLS), and petrolatum. The first nine were deemed positive. Factors aiding clinical relevance are listed.
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