US EPA

1639228 

Journal Article 

An approach for integrating toxicogenomic data in risk assessment: The dibutyl phthalate case study 

Euling, SY; Thompson, CM; Chiu, WA; Benson, R 

2013 

1 

Toxicology and Applied Pharmacology
ISSN: 0041-008X
EISSN: 1096-0333 

ACADEMIC PRESS INC ELSEVIER SCIENCE 

SAN DIEGO 

271 

3 

324-335 

English 

23537663 

10.1016/j.taap.2013.03.013 

WOS:000324669500004 

https://search.proquest.com/docview/1746326515?accountid=171501
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An approach for evaluating and integrating genomic data in chemical risk assessment was developed based on the lessons learned from performing a case study for the chemical dibutyl phthalate. A case study prototype approach was first developed in accordance with EPA guidance and recommendations of the scientific community. Dibutyl phthalate (DBP) was selected for the case study exercise. The scoping phase of the dibutyl phthalate case study was conducted by considering the available DBP genomic data, taken together with the entire data set, for whether they could inform various risk assessment aspects, such as toxicodynamics, toxicokinetics, and dose-response. A description of weighing the available dibutyl phthalate data set for utility in risk assessment provides an example for considering genomic data for future chemical assessments. As a result of conducting the scoping process, two questions-Do the DBP toxicogenomic data inform 1) the mechanisms or modes of action?, and 2) the interspecies differences in toxicodynamics?-were selected to focus the case study exercise. Principles of the general approach include considering the genomics data in conjunction with all other data to determine their ability to inform the various qualitative and/or quantitative aspects of risk assessment, and evaluating the relationship between the available genomic and toxicity outcome data with respect to study comparability and phenotypic anchoring. Based on experience from the DBP case study, recommendations and a general approach for integrating genomic data in chemical assessment were developed to advance the broader effort to utilize 21st century data in risk assessment. 

Phthalates; Toxicogenomic; Risk assessment; Endocrine disrupting chemical; Male development; Testosterone