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1737256 
Journal Article 
Borophosphate glass-ceramic scaffolds by a sodium silicate bonding process 
Liang, Wen; Tu, Y; Zhou, H; Liu, C; Ruessel, C 
2011 
1 
Journal of Non-Crystalline Solids
ISSN: 0022-3093
EISSN: 1873-4812 
357 
3 
958-962 
WOS:000288232500027 
A borophosphate glass with the mol% composition 25Na(2)O-25CaO-5P(2)O(3)-45B(2)O(5) was melted. The crystalline phase rheanite crystallized spontaneously during cooling the sample. Porous glass-ceramic scaffolds were prepared by bonding glass particles with size distributions in the range of approximately 100-500 pm by 0.1 M Na(2)SiO(3) solutions. The scaffolds porosities were 40-60% and their compressive strengths were 0.1 similar to 0.4 MPa. The conversion of the binding scaffolds to hydroxyapatite (HA) was investigated by measuring the weight loss after soaking the sample in a solution of 0.25 M K(2)HPO(4) with a pH value of 9.0 at 37 degrees C as a function of time. Hydroxyapatite (HA) was observed by XRD and SEM after soaking for 7 days. Cell attachment, spreading and proliferation on both unconverted scaffolds and on scaffolds coated with HA were determined by MIT [3-(4.5-Dimethylthiazol-2-yl)-2,5-Diphenyltetrazolium Bromide) assay method using Murine osteoblastic-like MC3T3-E1 cells. The scaffolds are biocompatible and their biocompatibility is enhanced after the formation of a HA layer. (C) 2010 Elsevier B.V. All rights reserved. 
Borophosphate glass; Scaffold; Hydroxyapatite