Jump to main content
US EPA
United States Environmental Protection Agency
Search
Search
Main menu
Environmental Topics
Laws & Regulations
About EPA
Health & Environmental Research Online (HERO)
Contact Us
Print
Feedback
Export to File
Search:
This record has one attached file:
Add More Files
Attach File(s):
Display Name for File*:
Save
Citation
Tags
HERO ID
1788334
Reference Type
Journal Article
Subtype
Review
Title
Toxic agents causing cerebellar ataxias
Author(s)
Manto, M
Year
2012
Is Peer Reviewed?
Yes
Journal
Handbook of Clinical Neurology
ISSN:
0072-9752
EISSN:
2212-4152
Volume
103
Page Numbers
201-213
Language
English
PMID
21827890
DOI
10.1016/B978-0-444-51892-7.00012-7
Abstract
The cerebellum is particularly vulnerable to intoxication and poisoning, especially so the cerebellar cortex and Purkinje neurons. In humans, the most common cause of a toxic lesion to the cerebellar circuitry is alcohol related, but the cerebellum is also a main target of drug exposure (such as anticonvulsants, antineoplastics, lithium salts, calcineurin inhibitors), drug abuse and addiction (such as cocaine, heroin, phencyclidine), and environmental toxins (such as mercury, lead, manganese, toluene/benzene derivatives). Although data for the prevalence and incidence of cerebellar lesions related to intoxication and poisoning are still unknown in many cases, clinicians should keep in mind the list of agents that may cause cerebellar deficits, since toxin-induced cerebellar ataxias are not rare in daily practice. Moreover, the patient's status may require immediate therapies when the intoxication is life-threatening.
Tags
•
Trimethylbenzenes (Interagency Science Discussion Draft)
Literature Search for Related Compounds
Cited
Considered
Cited August 2016
Cited Toxicological Review
Home
Learn about HERO
Using HERO
Search HERO
Projects in HERO
Risk Assessment
Transparency & Integrity