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Citation
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HERO ID
1788504
Reference Type
Journal Article
Subtype
Review
Title
Joint toxicity of alkoxyethanol mixtures: contribution of in silico applications
Author(s)
Pohl, HR; Ruiz, P; Scinicariello, F; Mumtaz, MM
Year
2012
Is Peer Reviewed?
1
Journal
Regulatory Toxicology and Pharmacology
ISSN:
0273-2300
EISSN:
1096-0295
Volume
64
Issue
1
Page Numbers
134-142
Language
English
PMID
22749914
DOI
10.1016/j.yrtph.2012.06.008
Web of Science Id
WOS:000308270400016
Abstract
Exposure to chemicals occurs often as mixtures. Presented in this paper is information on alkoxyethanols and the impact they might have on human health in combination with some commonly found aliphatic and aromatic compounds. Our studies to evaluate the joint toxicity of these chemicals among themselves and in combination with other chemicals reveal a variety of possible outcomes depending on the exposure scenario. The interactions are predominantly based on metabolic pathways and are common among several solvents and organic compounds. Quantitative structure activity relationship (QSAR) analysis can be used with high confidence to identify chemicals that will interact to influence overall joint toxicity. Potential human exposure to a combination of alkoxyethanol, toluene and substituted benzenes may increase reproductive and developmental disease conditions. Inheritable gene alterations result in changes in the enzyme function in different subpopulations causing variations in quantity and/or quality of particular isoenzymes. These changes are responsible for differential metabolism of chemicals in species, genders, and life stages and are often the basis of a population's susceptibility. Unique genotypes introduced as a function of migration can alter the genetic makeup of any given population. Hence special consideration should be given to susceptible populations while conducting chemical health risk assessments.
Tags
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Trimethylbenzenes (Interagency Science Discussion Draft)
Literature Search for Related Compounds
Considered
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