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Citation
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HERO ID
1797767
Reference Type
Journal Article
Title
Protective effects of Vernonia amygdalina against sodium arsenite-induced genotoxicity in rat
Author(s)
Adetutu, A; Oyewo, EB; Adesokan, AA
Year
2013
Is Peer Reviewed?
1
Journal
Pharmacognosy Research
ISSN:
0976-4836
EISSN:
0974-8490
Volume
5
Issue
3
Page Numbers
207-211
Language
English
PMID
23900237
DOI
10.4103/0974-8490.112431
URL
http://www.phcogres.com/text.asp?2013/5/3/207/112431
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Abstract
OBJECTIVES:
Contamination of the environment with arsenic (As) from both human and natural sources is known as a global problem. This study investigated the chemoprotective potential of Vernonia amygdalina leave extract against sodium arsenite-induced genotoxicity and hepatotoxicity.
MATERIALS AND METHODS:
Genotoxic effects were evaluated in the rat bone marrow using micronuclei. The gamma glutamyl transpeptidase (GGT) and alkaline phosphatase (ALP) activities were assayed in rat serum.
RESULTS:
Pre-treatment with extract of V. amygdalina at doses 5 mg/kg and 10 mg/kg significantly decreased the frequency of micronucleated polychromatic erythrocytes (PCEs). The GGT and ALP activities were elevated more than fourfold, in the liver of rats treated with sodium arsenite, while it was reduced almost to half when the sodium arsenit-treated rats were fed fresh V. amgdalina leave extracts The phytochemical constituents of V. amygdalina assayed in this study may be responsible for high radical scavenging of the DPPH free radical observed.
CONCLUSION:
The present results indicate that V. amygdalina extract is capable of suppressing the chromosomal aberration induced by sodium arsenite in rat. Thus, V. amygdalina may be a potent chemoprotective agent against the toxicity of sodium arsenite in rats.
Tags
IRIS
•
Arsenic Hazard ID
PubMed
Considered New
ToxNet
Considered New
ToxNet
Excluded
Toxnet Duplicates
ToxNet
Excluded
Toxnet Duplicates
ToxNet
Excluded
Toxnet Duplicates
ToxNet
Excluded
Toxnet Duplicates
2. Lit Search Updates through Oct 2015
PubMed
ToxNet
Considered
7. Other Studies through Oct 2015
MOA
Not Relevant
•
Arsenic (Inorganic)
1. Literature
Lit search updates through Oct 2015
3. Hazard ID Screening
Other potentially supporting studies
4. Adverse Outcome Pathways/Networks Screening
Relevant
•
Arsenic MOA
4. Adverse Outcome Pathways
Non-oxidative DNA/ chromosomal damage
1. MOA Literature Screening
Health Effect Screening
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