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HERO ID
1797821
Reference Type
Journal Article
Subtype
Review
Title
In utero and early life arsenic exposure in relation to long-term health and disease
Author(s)
Farzan, SF; Karagas, MR; Chen, Y
Year
2013
Is Peer Reviewed?
1
Journal
Toxicology and Applied Pharmacology
ISSN:
0041-008X
EISSN:
1096-0333
Volume
272
Issue
2
Page Numbers
384-390
Language
English
PMID
23859881
DOI
10.1016/j.taap.2013.06.030
Web of Science Id
WOS:000325905500014
Abstract
BACKGROUND:
There is a growing body of evidence that prenatal and early childhood exposure to arsenic from drinking water can have serious long-term health implications.
OBJECTIVES:
Our goal was to understand the potential long-term health and disease risks associated with in utero and early life exposure to arsenic, as well as to examine parallels between findings from epidemiological studies with those from experimental animal models.
METHODS:
We examined the current literature and identified relevant studies through PubMed by using combinations of the search terms "arsenic", "in utero", "transplacental", "prenatal" and "fetal".
DISCUSSION:
Ecological studies have indicated associations between in utero and/or early life exposure to arsenic at high levels and increases in mortality from cancer, cardiovascular disease and respiratory disease. Additional data from epidemiologic studies suggest intermediate effects in early life that are related to risk of these and other outcomes in adulthood. Experimental animal studies largely support studies in humans, with strong evidence of transplacental carcinogenesis, atherosclerosis and respiratory disease, as well as insight into potential underlying mechanisms of arsenic's health effects.
CONCLUSIONS:
As millions worldwide are exposed to arsenic and evidence continues to support a role for in utero arsenic exposure in the development of a range of later life diseases, there is a need for more prospective studies examining arsenic's relation to early indicators of disease and at lower exposure levels.
Keywords
Arsenic; Cancer; Cardiovascular; In utero; Prenatal; Respiratory
Tags
•
Arsenic Hazard ID
PubMed
Considered New
ToxNet
Considered New
PubMed
ToxNet
Excluded
Toxnet Duplicates
WOS
ToxNet
Excluded
Toxnet Duplicates
ToxNet
Excluded
Reviews
Toxnet Duplicates
2. Lit Search Updates through Oct 2015
PubMed
WOS
ToxNet
Initial Filter
Reviews
Considered
7. Other Studies through Oct 2015
Review/Risk Assessment/Guidance document
•
Arsenic (Inorganic)
1. Literature
Lit search updates through Oct 2015
Cited in Volume 1
•
Arsenic Susceptibility
4. Susceptibility and Lifestages
Lifestages
5. Health Effect
Reproductive System Effects including Pregnancy Outcomes
1. Susceptibility Literature Screening
Supplemental Search
2. Excluded
Not Relevant
3. References Identified During Review
Life Stages Citation Mapping
Top 5%
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