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1797821 
Journal Article 
Review 
In utero and early life arsenic exposure in relation to long-term health and disease 
Farzan, SF; Karagas, MR; Chen, Y 
2013 
Yes 
Toxicology and Applied Pharmacology
ISSN: 0041-008X
EISSN: 1096-0333 
272 
384-390 
English 
BACKGROUND: There is a growing body of evidence that prenatal and early childhood exposure to arsenic from drinking water can have serious long-term health implications.

OBJECTIVES: Our goal was to understand the potential long-term health and disease risks associated with in utero and early life exposure to arsenic, as well as to examine parallels between findings from epidemiological studies with those from experimental animal models.

METHODS: We examined the current literature and identified relevant studies through PubMed by using combinations of the search terms "arsenic", "in utero", "transplacental", "prenatal" and "fetal".

DISCUSSION: Ecological studies have indicated associations between in utero and/or early life exposure to arsenic at high levels and increases in mortality from cancer, cardiovascular disease and respiratory disease. Additional data from epidemiologic studies suggest intermediate effects in early life that are related to risk of these and other outcomes in adulthood. Experimental animal studies largely support studies in humans, with strong evidence of transplacental carcinogenesis, atherosclerosis and respiratory disease, as well as insight into potential underlying mechanisms of arsenic's health effects.

CONCLUSIONS: As millions worldwide are exposed to arsenic and evidence continues to support a role for in utero arsenic exposure in the development of a range of later life diseases, there is a need for more prospective studies examining arsenic's relation to early indicators of disease and at lower exposure levels. 
Arsenic; Cancer; Cardiovascular; In utero; Prenatal; Respiratory 
• Arsenic Hazard ID
          PubMed
          Considered New
          ToxNet
          Considered New
          PubMed
          ToxNet
          Excluded
               Toxnet Duplicates
          WOS
          ToxNet
          Excluded
               Toxnet Duplicates
          ToxNet
          Excluded
               Reviews
               Toxnet Duplicates
     2. Lit Search Updates through Oct 2015
          PubMed
          WOS
          ToxNet
          Initial Filter
               Reviews
          Considered
     7. Other Studies through Oct 2015
          Review/Risk Assessment/Guidance document
• Arsenic (Inorganic)
     1. Literature
          Lit search updates through Oct 2015
     Cited in Volume 1
• Arsenic Susceptibility
     4. Susceptibility and Lifestages
          Lifestages
     5. Health Effect
          Reproductive System Effects including Pregnancy Outcomes
     1. Susceptibility Literature Screening
          Supplemental Search
     2. Excluded
          Not Relevant
     3. References Identified During Review
     Life Stages Citation Mapping
          Top 5%