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Technical Report 
EPA Report 
Integrated science assessment for particulate matter 
U.S. Environmental Protection Agency :: U.S. EPA 
U.S. Environmental Protection Agency, Office of Research and Development, National Center for Environmental Assessment- RTP Division 
Research Triangle Park, NC 
EPA has released the final Integrated Science Assessment (ISA) for Particulate Matter (PM). This is EPA’s latest evaluation of the scientific literature on the potential human health and welfare effects associated with ambient exposures to particulate matter (PM). The development of this document is part of the Agency's periodic review of the national ambient air quality standards (NAAQS) for PM. The recently completed PM ISA and supplementary annexes, in conjunction with additional technical and policy assessments developed by EPA’s Office of Air and Radiation, will provide the scientific basis to inform EPA decisions related to the review of the current PM NAAQS.

PM is one of six principal (or criteria) pollutants for which EPA has established NAAQS. Periodically, EPA reviews the scientific basis for these standards by preparing an ISA (formerly called an Air Quality Criteria Document). The ISA and supplementary annexes, in conjunction with additional technical and policy assessments, provide the scientific basis for EPA decisions on the adequacy of the current NAAQS and the appropriateness of possible alternative standards. The Clean Air Scientific Advisory Committee (CASAC), an independent science advisory committee whose existence and whose review and advisory functions are mandated by Section 109 (d) (2) of the Clean Air Act, is charged (among other things) with independent scientific review of EPA's air quality criteria.

The first and second drafts of the PM ISA were released on December 22, 2008 and July 31, 2009, respectively, for independent external peer review and public comment. These drafts were reviewed at public meetings of the CASAC PM Review Panel on April 1-2, 2009 and October 5-6, 2009, respectively. This final PM ISA has benefited from the expert comments received at the CASAC meetings and from public comments, and it has been revised accordingly. 
• Ammonia
     References added post peer review
• ISA-CO (2010 Final Project Page)
     2010 Final
• ISA-Lead (2013 Final Project Page)
          1st Draft
          2nd Draft
          3rd Draft
     Atmospheric and Exposure Sciencies
          1st Draft
               Atmospheric Science
          2nd Draft
          Final Cited
• ISA NOxSOx Ecology/Welfare (2017)
     Cited in First Draft
          Chapter 1
          Chapter 2
          Appendix D: Other ecological effects of PM deposition
• ISA-Ozone (2013 Final Project Page)
          1st Draft
          2nd Draft
          3rd Draft
     Atm/Exp Science
     Health Effects
     Cited in First ERD Nov2015
     Cited Second ERD Dec2016
• PM Provisional Assessment (2012 Project Page)
• Nanoscale Silver
     External Review Draft
     Final Case Study