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HERO ID
1807718
Reference Type
Journal Article
Title
Effects of individual and binary-combined commercial insecticides endosulfan, temephos, malathion and pirimiphos-methyl on biomarker responses in earthworm Eisenia andrei
Author(s)
Stepić, S; Hackenberger, BK; Velki, M; Lončarić, Z; Hackenberger, DK
Year
2013
Is Peer Reviewed?
Yes
Journal
Environmental Toxicology and Pharmacology
ISSN:
1382-6689
EISSN:
1872-7077
Publisher
ELSEVIER
Location
AMSTERDAM
Volume
36
Issue
2
Page Numbers
715-723
Language
English
PMID
23896224
DOI
10.1016/j.etap.2013.06.011
Web of Science Id
WOS:000324082900053
Abstract
Laboratory tests were conducted in order to investigate the effects of individual and binary-combined commercial insecticides endosulfan, temephos, malathion and pirimiphos-methyl on the earthworm Eisenia andrei. The effects of individual insecticides were determined by measuring the activities of acetylcholinesterase (AChE), catalase (CAT) and glutathione-S-transferase (GST). After exposure to studied insecticides, dose-dependent decrease in AChE activity and dose-dependent increase in CAT activity was recorded. The activity of GST was without consistent dose-response reaction, but generally the investigated insecticides caused the increase in GST activity. In order to determine the effects of binary-combined mixtures, and interactions between the components in the mixture, the relationship between effective concentration of AChE inhibition for mixture and effective concentration of AChE inhibition for each component in the mixture was investigated. The obtained results showed additive effect for mixtures endosulfan+malathion; endosulfan+pirimiphos-methyl; temephos+malathion and temephos+pirimiphos-methyl, synergistic effect for mixture endosulfan+temephos and in the case of mixture malathion+pirimiphos-methyl the antagonistic effect was indicated.
Keywords
Insecticide; Mixture; Biomarker; Organophosphate; Organochlorine; Earthworm
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