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Citation
Tags
HERO ID
1936064
Reference Type
Journal Article
Title
Effects of sodium arsenate exposure on liver fatty acid profiles and oxidative stress in rats
Author(s)
Kharroubi, W; Dhibi, M; Haouas, Z; Chreif, I; Neffati, F; Hammami, M; Sakly, R
Year
2014
Is Peer Reviewed?
Yes
Journal
Environmental Science and Pollution Research
ISSN:
0944-1344
EISSN:
1614-7499
Volume
21
Issue
3
Page Numbers
1648-1657
Language
English
PMID
23949113
DOI
10.1007/s11356-013-2057-3
Web of Science Id
WOS:000330970400005
URL
http://link.springer.com/10.1007/s11356-013-2057-3
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Abstract
The present study aimed to evaluate the effect of arsenic on liver fatty acids (FA) composition, hepatotoxicity and oxidative status markers in rats. Male rats were randomly devised to six groups (n = 10 per group) and exposed to sodium arsenate at a dose of 1 and 10 mg/l for 45 and 90 days. Arsenate exposure is associated with significant changes in the FA composition in liver. A significant increase of saturated fatty acids (SFA) in all treated groups (p < 0.01) and trans unsaturated fatty acids (trans UFA) in rats exposed both for short term for 10 mg/l (p < 0.05) and long term for 1 and 10 mg/l (p < 0.001) was observed. However, the cis UFA were significantly decreased in these groups (p < 0.05). A markedly increase of indicator in cell membrane viscosity expressed as SFA/UFA was reported in the treated groups (p < 0.001). A significant increase in the level of malondialdehyde by 38.3 % after 90 days of exposure at 10 mg/l was observed. Compared to control rats, significant liver damage was observed at 10 mg/l of arsenate by increasing plasma marker enzymes after 90 days. It is through the histological investigations in hepatic tissues of exposed rats that these damage effects of arsenate were confirmed. The antioxidant perturbations were observed to be more important at groups treated by the high dose (p < 0.05). An increase in the level of protein carbonyls was observed in all treated groups (p < 0.05). The present study provides evidence for a direct effect of arsenite on FA composition disturbance causing an increase of SFA and TFAs isomers, liver dysfunction and oxidative stress. Therefore, arsenate can lead to hepatic damage and propensity towards liver cancer.
Keywords
Arsenate; trans fatty acids; Oxidative stress; Hepatotoxicity; Rats
Tags
•
Arsenic Hazard ID
PubMed
Considered New
PubMed
WOS
Considered New
WOS
ToxNet
Excluded
WOS Duplicates
WOS
ToxNet
Excluded
Toxnet Duplicates
WOS Duplicates
2. Lit Search Updates through Oct 2015
PubMed
WOS
ToxNet
Considered
7. Other Studies through Oct 2015
MOA
8. Hazard through Oct 2015
Animal Hazard ID
•
Arsenic (Inorganic)
1. Literature
Lit search updates through Oct 2015
Identified during manual review of authoritative sources
3. Hazard ID Screening
Other potentially supporting studies
4. Adverse Outcome Pathways/Networks Screening
Relevant
5. Susceptibility Screening
Excluded/Not relevant
•
Arsenic MOA
4. Adverse Outcome Pathways
Oxidative stress related effects (includes non-specific SH reactions)
5. Health Effect
Liver Effects
1. MOA Literature Screening
Health Effect Screening
Susceptibility Screening
•
Arsenic Susceptibility
5. Health Effect
Liver Effects
Other Health Effects
1. Susceptibility Literature Screening
Supplemental Search
2. Excluded
MOA/Mechanistic
3. References Identified During Review
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