Chen, C; Jiang, X; Zhao, W; Zhang, Z
The potential benefits of resveratrol as an anticancer (proapoptosis) and antioxidant (pro-survival) compound have been studied extensively. However, the role of resveratrol in modulation of the toxicity induced by sodium arsenite (NaAsO2) is still unclear. In the present study, we examined the effects of resveratrol on NaAsO2-induced cytotoxicity, DNA and chromosomal damage, cell cycle progression, apoptosis and oxidative stress in human lung adenocarcinoma epithelial (A549) cell line at concentrations from 1 to 20μM after 24h exposure. Our results revealed that at 1 and 5μM, resveratrol was found to exert benefit effects, promoting cell viability and proliferation over 24h NaAsO2 exposure, whereas, resveratrol was showed to inhibit cell survival under the same condition at 20μM. Corresponding to the opposing effect of resveratrol at low vs. high concentrations, DNA and chromosomal damage, cell apoptotic rate and level of oxidative stress were also alleviated by lower concentrations (1, 5μM) of resveratrol, but exacerbated by higher concentration (20μM) resveratrol. Our study implicates that resveratrol is the most beneficial to cells at 1 and 5μM and caution should be taken in applying resveratrol as an anticancer therapeutic agent or nutraceutical supplement due to its concentration dependent effect.
