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195021 
Journal Article 
The genotoxicity of 1,4-dioxane 
Ashby, J 
1994 
1 
Mutation Research
ISSN: 0027-5107
EISSN: 1873-135X 
Mutation Research 
322 
2 
141-142 
English 
7519321 
WOS:A1994PM07000008 
Abstract: 1,4-Dioxane is a simple cyclic ether. It is the type of chemical that one hopes and even assumes is unlikely to be mutagenic or carcinogenic. In 1978, the National Cancer Institute reported that 1,4-dioxane induced liver tumors in both sexes of mice and nasal tumors in both sexes of rat. In 1990, Kitchin and Brown reviewed the available mutagenicity, genotoxicity and tumor promoting data for this chemical and concluded that it was best described as a weak genotoxin which also possesses strong activity as a promoter of (liver) carcinogenesis. Despite the limited evidence of weak genotoxicity discussed by Kitchin and Brown, it is worth noting that 1,4-dioxane is negative in the Salmonella assay and the CHO chromosome aberration assay. ds: dioxane evised - 2006-11-01 e field[29]: 1,4-Dioxane 
Animals; Carcinogens toxicity; Dioxanes toxicity; Mice; Mice Inbred BALB C; Mice Inbred C57BL; Mutagenicity Tests; Mutagens toxicity; Nose Neoplasms chemically induced; Rats 
IRIS
• 1,4-Dioxane - with inhalation update
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     External Review Draft (2011)
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• OPPT_1,4-Dioxane_D. Exposure
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• OPPT_1,4-Dioxane_F. Human Health
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