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Citation
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HERO ID
1955012
Reference Type
Journal Article
Title
Fabrication of Novel Gastro-Retentive Floating Microcapsules by Utilizing a Combination of HPMC and EC and their Physicochemical Assessment
Author(s)
Aamir, MN; Ahmad, M; Khan, SA; Akhtar, N; Murtaza, G; Akhtar, M; Rasool, F
Year
2011
Is Peer Reviewed?
0
Journal
Latin American Journal of Pharmacy
ISSN:
0326-2383
Volume
30
Issue
5
Page Numbers
1010-1015
Web of Science Id
WOS:000295064000028
Abstract
The project was aimed to develop floating microcapsules (FMs) using combination of a hydrophobic (ethyl cellulose, EC) and hydrophilic polymer (hydroxy propyl methyl cellulose, HPMC), and to evaluate them. An easy and novel phase separation method was adopted to prepare FMs. Chloroform and paraffin oil were employed as solvent and non-solvent respectively. Five kinetic models were applied to assess and describe the mechanism and pattern of tramadol hydrochloride (TmH) release from FMs and they were subjected to FTIR and XRD to evaluate TmH-HPMC-EC interaction. As EC concentration was increased the retardation in drug release, improvement in flow characteristics and decrease in floating time were observed. Kinetics of drug release was followed by Korsmeyer-Peppas kinetic model. It was concluded that the floating microcapsules of TmH can be produced using phase separation method and they have no drug-polymer interaction. The accelerated stability studies also ensured the physicochemical integrity of FMs.
Keywords
Floating microcapsules; Non-solvent addition; Polymers combination; Tramadol
Tags
•
Chloroform 2018 Update
TITLE AND ABSTRACT REVIEW
Excluded Studies
•
Chloroform Combined (current)
Chloroform (original)
References: 2000-2018
WoS
Chloroform (2018 update)
TITLE AND ABSTRACT REVIEW
Excluded Studies
Chloroform (current)
Literature Search: Jan 2009 - March 2017
Web of Science
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