US EPA

1974278 

Journal Article 

Main neurodevelopmental study of Seychellois children following in utero exposure to methylmercury from a maternal fish diet: Outcome at six months 

Myers, GJ; Marsh, DO; Davidson, PW; Cox, C; Shamlaye, CF; Tanner, M; Choi, A; Cernichiari, E; Choisy, O; Clarkson, TW 

1995 

1 

NeuroToxicology
ISSN: 0161-813X
EISSN: 1872-9711 

16 

4 

653-663 

English 

8714870 

WOS:A1995TU78900007 

http://://WOS:A1995TU78900007
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A 6 month followup was conducted as part of the Seychelles Child Development Study examining the relationship between low level dietary methylmercury exposure and fetal neurotoxicology in infants born to mothers with a high dietary intake of oceanic fish. Neurological tests, the Fagen test of visual recognition memory, and the Denver Developmental Screening Test Revised (DDST-R) were performed on children 6 1/2 months of age by an examiner blinded to maternal mercury levels. The mean hair mercury (7439976) level of the 740 mothers was 5.9 parts per million. Two percent of the infants tested scored other than normal on the DDST-R and 3.4% had neurological scores other than normal. A median score of 60.5% was seen on the Fagen test of visual recognition memory with a median score of 37.9 on the Rose attention measure from that test. Multiple regression analysis did not demonstrate a significant association between maternal hair mercury level during pregnancy and adverse neurological outcome in infants. 

fetus; methylmercury; neurodevelopment; newborn; infant; fish; Seychelles