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Citation
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HERO ID
1987639
Reference Type
Journal Article
Title
Urinary phthalate metabolites and male reproductive function parameters in Chongqing general population, China
Author(s)
Han, X; Cui, Z; Zhou, N; Ma, M; Li, L; Li, Y; Lin, H; Ao, L; Shu, W; Liu, J; Cao, J
Year
2014
Is Peer Reviewed?
Yes
Journal
International Journal of Hygiene and Environmental Health
ISSN:
1438-4639
EISSN:
1618-131X
Publisher
Elsevier
Volume
217
Issue
2-3
Page Numbers
271-278
Language
English
PMID
23906849
DOI
10.1016/j.ijheh.2013.06.006
Web of Science Id
WOS:000331595500018
URL
https://search.proquest.com/docview/1492674405?accountid=171501
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Abstract
This study was designed to investigate the phthalates exposure levels in general population in Chongqing City of China, and to determine the possible associations between phthalate exposure and male reproductive function parameters. We recruited 232 general men through Chongqing Family Planning Research Institute and Reproductive Center of Chongqing. In a single spot urine sample from each man, phthalate metabolites, including mono-butyl phthalate (MBP), mono-ethyl phthalate (MEP), mono-(2-ethylhexyl) phthalate (MEHP), mono-benzyl phthalate (MBzP), phthalic acid (PA), and total PA were analyzed using solid phase extraction and coupled with high-performance liquid chromatography and detection by tandem mass spectrometry. Semen parameters were dichotomized based on World Health Organization reference values. Sperm DNA damage were analyzed using the alkaline single-cell gel electrophoresis assay. Reproductive hormones were determined in serum by the radioimmunoassay kit. We observed a weak association between urinary MBP concentration and sperm concentration in Chongqing general population. MBP levels above the median were 1.97 times (95% confidence interval [CI] 0.97-4.04) more likely to have sperm concentration below the reference value. There were no other associations between phthalate metabolites and reproductive function parameters after adjusted for potential risk factors. Our study suggested that general population in Chongqing area of China exposure to the environmental level of phthalate have weak or without adverse effects on the reproduction.
Keywords
Phthalate; Semen; Sperm; Metabolites; DAN damage; Hormone; Human; Male; Reproduction
Tags
IRIS
•
BBP (Butyl benzyl phthalate)
•
Dibutyl Phthalate (DBP)
•
Diethyl phthalate (DEP)
Database searches
Aug 2013 update
Pubmed
Jul 2014 update
Pubmed
Jan 2020 update
PubMed
Web of Science
Primary source of health effects
Human health effects studies
•
Phthalates – Targeted Search for Epidemiological Studies
Source – all searches
Pubmed
WOS
Included
DEHP
DBP
DEP
Source - Dec 2013 Update (Private)
Pubmed
Source - Jun 2014 Update (Private)
WOS
Source – Dec 2014 Update (Private)
Pubmed
WOS
Source – Mar 2015 Update (Private)
WOS
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