US EPA

1987640 

Journal Article 

Comparative antioxidant responses in liver of Carassius auratus exposed to phthalates: An integrated biomarker approach 

Zheng, Q; Feng, M; Dai, Y 

2013 

Yes 

Environmental Toxicology and Pharmacology
ISSN: 1382-6689
EISSN: 1872-7077 

Elsevier B.V. 

Environmental toxicology and pharmacology 

36 

3 

741-749 

English 

23938764 

10.1016/j.etap.2013.07.008 

WOS:000329530600001 

http://dx.doi.org/10.1016/j.etap.2013.07.008 Available from publisher's site
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Phthalates (PAEs) are chemical agents typically used as plasticizers in numerous industrial products. They have become ubiquitous contaminants due to their tendency to release into the environment. The present study was conducted to investigate the comparative antioxidant responses in liver of freshwater goldfish Carassius auratus injected intraperitoneally with 17 different PAEs at a concentration of 10mg/kg for 10 days. The results indicated that these PAEs can adversely affect the antioxidant status, confirmed by the significantly inhibited activities of antioxidant enzymes (superoxide dismutase, catalase, and glutathione peroxidase). Especially, the latter two enzymes constituted the most affected antioxidant enzymes after the exposure, and the lowest values were recorded for the catalase activity. The toxicity order was proposed via the integrated biomarker response, with dicyclohexyl phthalate the most toxic and diethyl phthalate the least. Overall, these findings may contribute to the risk assessments of these chemicals on aquatic species. 

Carassius auratus; antioxidant activity; antioxidants; biomarkers; catalase; freshwater; glutathione peroxidase; goldfish; phthalates; plasticizers; risk assessment; superoxide dismutase; toxicity; Internet resource