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Tags
HERO ID
2088474
Reference Type
Journal Article
Title
Modulatory of effect of fresh Amaranthus caudatus and Amaranthus hybridus aqueous leaf extracts on detoxify enzymes and micronuclei formation after exposure to sodium arsenite
Author(s)
Adewale, A; Olorunju, AE
Year
2013
Is Peer Reviewed?
1
Journal
Pharmacognosy Research
ISSN:
0976-4836
EISSN:
0974-8490
Volume
5
Issue
4
Page Numbers
300-305
Language
English
PMID
24174825
DOI
10.4103/0974-8490.118819
Abstract
Vegetables are the cheapest and most available sources of important proteins, minerals, vitamins, and essential amino protein. These vegetables are commonly used in Africa for the treatment of illness. This study evaluated the protective effects of Amaranthus caudatus and A. hybridus against sodium arsenite-induced toxicity in rats. The effects of sodium arsenite and/or the plant extracts were assessed using bone marrow micronucleus assay and by measuring the activities of tumour maker enzymes such as gamma glutamyl transferase (GGT) and alkaline phosphatase (ALP) in white albino Wister rats. The study showed that sodium arsenite significantly (P < 0.05) induced the formation of micronucleated polychromatic erythrocytes and the activities of ALP and GGT when compared with control. The levels of white blood cell, hemoglobin, and lymphocyte count were altered in sodium arsenite fed rats and were reverted back to near normal levels in rats pretreated with the plant extracts. A. caudatus and A. hybridus showed significant role in protecting the detoxifying enzymes; also, A. caudatus has a more protective effect on reducing the micronuclei formation when compared with A. hybridus. This study suggests that A. caudatus and A. hybridus possess anticarcinogenic effect.
Tags
IRIS
•
Arsenic Hazard ID
PubMed
Considered New
ToxNet
Considered New
ToxNet
Excluded
Toxnet Duplicates
2. Lit Search Updates through Oct 2015
PubMed
ToxNet
Considered
7. Other Studies through Oct 2015
MOA
Not Relevant
•
Arsenic (Inorganic)
1. Literature
Lit search updates through Oct 2015
3. Hazard ID Screening
Other potentially supporting studies
4. Adverse Outcome Pathways/Networks Screening
Relevant
•
Arsenic MOA
4. Adverse Outcome Pathways
Non-oxidative DNA/ chromosomal damage
1. MOA Literature Screening
Health Effect Screening
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