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2088480 
Journal Article 
Chelator-free synthesis of a dual-modality PET/MRI agent 
Chen, F; Ellison, PA; Lewis, CM; Hong, H; Zhang, Y; Shi, S; Hernandez, R; Meyerand, ME; Barnhart, TE; Cai, W 
In Press 
Yes 
Angewandte Chemie (International Edition)
ISSN: 1433-7851
EISSN: 1521-3773 
52 
50 
13319-13323 
English 
Old technique, new application: A simple and efficient chelator-free strategy for the synthesis of a novel dual-modality PET/MRI agent has been developed. Labeling of radioarsenic (*As(III) and *As(V) , *=71, 72, 74, 76) at the surface of superparamagnetic iron oxide nanoparticles (SPIONs) resulted in *As-SPIONs that can be used for simultaneous PET/MRI in cancer diagnosis, lymph-node mapping, and potentially for internal radiotherapy. 
arsenic; cancer; magnetic resonance imaging; positron emission tomography; radiochemistry 
IRIS
• Arsenic Hazard ID
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