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HERO ID
2135769
Reference Type
Journal Article
Title
The effect of the cytochrome P-450 system inducers on the development of Drosophila melanogaster
Author(s)
Fuchs, SY; Spiegelman, VS; Belitsky, GA
Year
1993
Is Peer Reviewed?
Yes
Journal
Journal of Biochemical Toxicology
ISSN:
0887-2082
EISSN:
1522-7146
Volume
8
Issue
2
Page Numbers
83-88
Language
English
PMID
8355263
DOI
10.1002/jbt.2570080205
Web of Science Id
WOS:A1993LL37400004
Abstract
D. melanogaster development was markedly retarded and its survival decreased by larvae treatment with compounds being strong inducers of the cytochrome P-450 2B in mammals— phenobarbital (PB*), perfluorodecaline (PFD), transstilbene oxide (TSO), and triphenyldioxane (TPD). At the same time, the weak inducer hexobarbital or the selective cytochrome P-450 inducer in mice but not in rats 1,4-bis[2-(dichloropyridyl-oxy)]-benzene (DPB) did not affect the larvae development. The cytochrome P-450 1A1 inducers benzo(a)anthracene (BA) and β-naphtoflavone (BNF) were also not effective. The toxicity of phenobarbital was shown to be decreased by the cytochrome P-450 inhibitor piperonyl butoxide by adding 20-hydroxyecdysone or by treatment with aminophylline—the indirect enhancer of ecdysone production in the larval prothoracic gland. The hypothesis of the moulting hormone degradation as the cause of elevated larvae mortality resulting from the induced high mixed function oxidase activity has been discussed.
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PFAS
•
^Per- and Polyfluoroalkyl Substances (PFAS)
PFDS (335-77-3)
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Toxline
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PFDS
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