US EPA

2215391 

Journal Article 

Estimated daily intake and hazard quotients and indices of phthtalate diesters for young danish men 

Kranich, SK; Frederiksen, H; Andersson, AM; Jørgensen, N 

2014 

1 

Environmental Science & Technology
ISSN: 0013-936X
EISSN: 1520-5851 

American Chemical Society 

Easton 

48 

1 

706-712 

English 

24228837 

10.1021/es402569k 

WOS:000329548800090 

https://search.proquest.com/docview/1500785758?accountid=171501
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Because of wide exposure to phthalates we investigated whether simultaneous exposure to several phthalates reached levels that might cause adverse anti-androgenic effects. 33 healthy young Danish men each delivered three 24-hour urine samples during a three months period. The daily intakes of the sum of di-n-butyl and di-iso-butyl phthalate, di(2-ethylhexyl) phthalate, di-iso-nonyl phthalate, and butylbenzyl phthalate were estimated based on urinary excretion of the metabolites. Based on a hazard quotient (HQ) of the individual phthalate (i.e. the ratio between the daily intake and an acceptable level of exposure), a hazard index (HI) for each man was calculated as the sum of HQs for the individual phthalates. All men were exposed to all phthalates during the urine collection periods. Median HIs were all below 1 (i.e. below an acceptable cumulative threshold) ranging from 0.11-0.17 over the three different sample collections. Of the 33 men two men had HIs above 1 in one of their three samples, indicating that occasionally the combined exposure to the investigated phthalates reached a level which may not be considered safe. Besides the phthalates investigated here humans are exposed to numerous other chemicals which also may contribute to a cumulative anti-androgenic exposure. 

Environment Abstracts; Excretion; Metabolites; Hazards; Chemicals; Phthalates; ENA 02:Toxicology & Environmental Safety