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HERO ID
2215403
Reference Type
Journal Article
Title
Early life phthalate exposure and atopic disorders in children: A prospective birth cohort study
Author(s)
Wang, IJ; Lin, CC; Lin, YJ; Hsieh, WS; Chen, PC
Year
2014
Is Peer Reviewed?
1
Journal
Environment International
ISSN:
0160-4120
EISSN:
1873-6750
Publisher
Elsevier
Book Title
Environ Int. 2014, Jan; 62:48-54. [Environment international]
Volume
62
Issue
Elsevier
Page Numbers
48-54
Language
English
PMID
24161446
DOI
10.1016/j.envint.2013.09.002
Web of Science Id
WOS:000329003000005
URL
https://search.proquest.com/docview/1685770084?accountid=171501
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Abstract
The role of phthalate exposure at different stages in the immune system and atopic disorders is not well-known. This study aims to evaluate the effects of prenatal and postnatal phthalate exposures on immunoglobulin E (IgE) levels and atopic dermatitis (AD) in children by objective biomarkers. We conducted a prospective Taiwan Birth Panel cohort study with 483 mother/infant pairs. Finally, 161 urine specimens at 3rd trimester of pregnancy, 219 urine specimens from children at age 2, and 192 urine specimens at age 5 were analyzed after excluding missing data and loss to follow-up. Urine monoethyl phthalate (MEP), monobutyl phthalate (MBP), monobenzyl phthalate (MBzP), and mono-(2-ethylhexyl) phthalate (MEHP) at 3rd trimester of pregnancy and at ages 2 and 5 were measured by ultra-performance liquid chromatography coupled with tandem mass spectrometry. At ages 2 and 5, information on the development of AD and serum total IgE was collected. The association between urine phthalate metabolite levels at different stages and serum IgE and AD was evaluated by multivariate linear regression and logistic regression. Urine phthalate metabolite levels were higher at age 2 than those at pregnancy and age 5. At each period, urine MBP levels were higher than MEP, MEHP, and MBzP. MEHP levels at age 2 positively correlated with serum IgE levels (per ln-unit: β=0.191, p=0.02). Analyses stratified by gender revealed that MEHP levels positively correlated with serum IgE levels only in boys (per ln-unit: β=0.256, p=0.03). When dividing into quartiles, urine MBzP levels at age 2 had a significant association with AD. We found no statistically significant association of other phthalate metabolites with IgE and AD. Early life phthalate exposure may increase the risk of allergic sensitization and atopic disorders.
Keywords
MEHP; MBzP; IgE; Atopic dermatitis; Cohort study
Tags
IRIS
•
BBP (Butyl benzyl phthalate)
Literature Search
LitSearch Aug 2013-Apr 2014
PubMed
Litsearch April 2014 - February 2015
Toxnet
Studies with Health Effects Data
Human health effects studies
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Dibutyl Phthalate (DBP)
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LitSearch June 2013 – Jan 2014
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Diethyl phthalate (DEP)
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Jan 2020 update
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Phthalates – Targeted Search for Epidemiological Studies
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DEHP
DBP
BBP
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Source - Dec 2013 Update (Private)
Pubmed
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Source - Jun 2014 Update (Private)
Pubmed
WOS
Source – Dec 2014 Update (Private)
WOS
Source – Mar 2015 Update (Private)
WOS
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