Jump to main content
US EPA
United States Environmental Protection Agency
Search
Search
Main menu
Environmental Topics
Laws & Regulations
About EPA
Health & Environmental Research Online (HERO)
Contact Us
Print
Feedback
Export to File
Search:
This record has one attached file:
Add More Files
Attach File(s):
Display Name for File*:
Save
Citation
Tags
HERO ID
2215423
Reference Type
Journal Article
Title
Entering markets and bodies: Increasing levels of the novel plasticizer Hexamoll(®) DINCH(®) in 24h urine samples from the German Environmental Specimen Bank
Author(s)
Schütze, A; Kolossa-Gehring, M; Apel, P; Brüning, T; Koch, HM
Year
2014
Is Peer Reviewed?
Yes
Journal
International Journal of Hygiene and Environmental Health
ISSN:
1438-4639
EISSN:
1618-131X
Publisher
Elsevier
Volume
217
Issue
2-3
Page Numbers
421-426
Language
English
PMID
24029725
DOI
10.1016/j.ijheh.2013.08.004
Web of Science Id
WOS:000331595500039
URL
http://
://WOS:000331595500039
Exit
Abstract
DINCH (diisononylcyclohexane-1,2-dicarboxylate) was introduced into the world market in 2002 as a non-aromatic plasticizer and phthalate substitute. We analyzed 300 urine samples (24h voids) of the German Environmental Specimen Bank (ESB for Human tissues, ESB Hum) for specific DINCH metabolites by on-line HPLC-MS/MS with isotope dilution quantification. Urine samples of the ESB Hum were from the years 1999, 2003, 2006, 2009 and 2012, chosen to investigate the appearance and a possible trend of DINCH exposure since its market introduction. No DINCH metabolites were detected in the 1999 and 2003 samples. From 2006 on, the percentage of samples with DINCH metabolites above the LOQ increased significantly over the years (7% in 2006, 43% in 2009 and 98% in 2012). The cyclohexane-1,2-dicarboxylic acid-mono(hydroxy-isononyl) ester (OH-MINCH) was the predominant metabolite. Median (and 95th percentile) concentrations (in μg/l) increased from <LOQ (0.09) in 2006, to <LOQ (1.02) in 2009 to 0.39 (2.09) in 2012. All oxidized DINCH metabolites (OH-MINCH, cx-MINCH, oxo-MINCH) correlated strongly among each other (ρ>0.75, p<0.001). The median (95th percentile) DINCH intake in 2012 was calculated to be 0.14 (1.07)μg/kg body weight/day which is considerably below daily intakes currently deemed tolerable. DINCH is regarded to have a preferred toxicological profile over certain anti-androgenic phthalates. The continuation of DINCH measurements in the ESB Hum and other human biomonitoring studies like the German Environmental Survey (GerES) allows tracking the development of DINCH body burdens, the distribution of exposure levels and daily intakes, providing basic data for future toxicological assessment and further epidemiological studies.
Keywords
Di(isononyl)cyclohexane-1,2-dicarboxylate; DINCH; Plasticizer; Exposure assessment; Urinary metabolites; Human biomonitoring
Tags
•
Phthalates – Targeted Search for Epidemiological Studies
Source – all searches
Pubmed
WOS
Excluded
Source - Dec 2013 Update (Private)
Pubmed
Source - Jun 2014 Update (Private)
WOS
Source – Dec 2014 Update (Private)
Pubmed
WOS
Source – Mar 2015 Update (Private)
WOS
Home
Learn about HERO
Using HERO
Search HERO
Projects in HERO
Risk Assessment
Transparency & Integrity