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HERO ID
2219808
Reference Type
Journal Article
Title
Phthalate intake by infants calculated from biomonitoring data
Author(s)
Völkel, W; Kiranoglu, M; Schuster, R; Fromme, H; HBMnet
Year
2014
Is Peer Reviewed?
1
Journal
Toxicology Letters
ISSN:
0378-4274
EISSN:
1879-3169
Publisher
ELSEVIER IRELAND LTD
Location
CLARE
Book Title
Toxicol Lett.
Volume
225
Issue
2
Page Numbers
222-229
Language
English
PMID
24374175
DOI
10.1016/j.toxlet.2013.12.012
Web of Science Id
WOS:000330580900004
URL
http://
://WOS:000330580900004
Exit
Abstract
Urine samples (n=207) of 47 infants between 1- and 5-month of age were quantitated for 12 metabolites of 7 phthalates and compared with samples collected from the mothers of the infants at different time points. Median and 95-percentile were lower for all metabolites in urine samples of infants compared to mothers. For di-2-ethylhexyl phthalate (DEHP) the 95-percentile daily intake was 23.3μg/kg b.w. for mothers and 5.4μg/kg b.w. for infants and for di-isobutyl phthalate (DiBP) 10.1μg/kg b.w. and 8.5μg/kg b.w. Some values exceeded the corresponding tolerable daily intake (TDI) for DiBP for infants and mothers and for DEHP and di-n-butyl phthalate (DnBP) only for mothers. Both, infants and mothers are able to efficiently form phase II metabolites but infants with a slightly lower degree. Therefore, a distinguished risk assessment with respect to the formed toxic metabolites of phthalates would be necessary in combination with a reduction of the most toxic phthalates.
Keywords
Infants; Biomonitoring; Phthalates; Risk assessment; Urinary excretion
Tags
•
Dibutyl Phthalate (DBP)
Database Searches
Pubmed
Web of Science
Litsearch September 2014 - February 2015
WOS
LitSearch June 2013 – Jan 2014
PubMed
LitSearch Jan 2014 - Sep 2014
PubMed
Web of Science
Excluded: No Primary Data on Health Effects
Exposure levels
•
Diisobutyl Phthalate (DIBP) Final
Database Searches
March 2014 Database Search
PubMed
Web of Science
September 2014 update
PubMed
Toxline
Web of Science
June 2015 Update
Toxline
Web of Science
December 2015 Update
Web of Science
June 2016 Update
Toxline
Web of Science
January 2017 Update
July 2017 Update
No Primary Data on Toxic Effects
Exposure levels
•
Phthalates – Targeted Search for Epidemiological Studies
Source – all searches
Pubmed
Excluded
Source - Jun 2014 Update (Private)
Pubmed
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