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HERO ID
2231329
Reference Type
Journal Article
Title
Effects of maternal exposure to di(2-ethylhexyl)phthalate (DEHP) during pregnancy on susceptibility to neonatal asthma
Author(s)
Shin, IS; Lee, MY; Cho, ES; Choi, EY; Son, HY; Lee, KY
Year
2014
Is Peer Reviewed?
1
Journal
Toxicology and Applied Pharmacology
ISSN:
0041-008X
EISSN:
1096-0333
Book Title
Toxicol Appl Pharmacol.
Volume
274
Issue
3
Page Numbers
402-407
Language
English
PMID
24370437
DOI
10.1016/j.taap.2013.12.009
Web of Science Id
WOS:000331155200005
URL
https://search.proquest.com/docview/1492708277?accountid=171501
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Abstract
Di(2-ethylhexyl) phthalate (DEHP) is used as a plasticizer and is widely dispersed in the environment. In this study, we investigated the effects of maternal exposure to DEHP during pregnancy on neonatal asthma susceptibility using a murine model of asthma induced by ovalbumin (OVA). Pregnant BALB/c mice received DEHP from gestation day 13 to lactation day 21. Their offspring were sensitized on postnatal days (PNDs) 9 and 15 by intraperitoneal injection of 0.5μg OVA with 200μg aluminum hydroxide. On PNDs 22, 23 and 24, live pups received an airway challenge of OVA for 30min. Offspring from pregnant mice that received DEHP showed reductions in inflammatory cell count, interleukin (IL)-4, IL-13, and eotaxin in their bronchoalveolar lavage fluid and in total immunoglobulin E and OVA-specific IgE in their plasma compared with offspring from pregnant mice that did not receive DEHP treatment. These results were consistent with histological analysis and immunoblotting. Maternal exposure to DEHP reduces airway inflammation and mucus production in offspring, with a decrease in inducible nitric oxide synthase (iNOS) in the lung tissue. This study suggests that maternal exposure to DEHP during pregnancy reduces asthmatic responses induced by OVA challenge in offspring. These effects were considered to be closely related to the suppression of Th2 immune responses and iNOS expression.
Keywords
Di(2-ethylhexyl)phthalate (DEHP); Maternal exposure; Pregnancy; Offspring; Asthma
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March 2014-November 2016
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