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Citation
Tags
HERO ID
2238712
Reference Type
Journal Article
Title
Influence of exposure assessment and parameterization on exposure response. Aspects of epidemiologic cohort analysis using the Libby Amphibole asbestos worker cohort
Author(s)
Bateson, TF; Kopylev, L
Year
2015
Is Peer Reviewed?
1
Journal
Journal of Exposure Science & Environmental Epidemiology
ISSN:
1559-0631
EISSN:
1559-064X
Volume
25
Issue
1
Page Numbers
12-17
Language
English
PMID
24496219
DOI
doi: 10.1038/jes.2014.3
Web of Science Id
WOS:000346431500003
URL
https://www.proquest.com/scholarly-journals/influence-exposure-assessment-parameterization-on/docview/2331627415/se-2?accountid=171501
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Abstract
Recent meta-analyses of occupational epidemiology studies identified two important exposure data quality factors in predicting summary effect measures for asbestos-associated lung cancer mortality risk: sufficiency of job history data and percent coverage of work history by measured exposures. The objective was to evaluate different exposure parameterizations suggested in the asbestos literature using the Libby, MT asbestos worker cohort and to evaluate influences of exposure measurement error caused by historically estimated exposure data on lung cancer risks. Focusing on workers hired after 1959, when job histories were well-known and occupational exposures were predominantly based on measured exposures (85% coverage), we found that cumulative exposure alone, and with allowance of exponential decay, fit lung cancer mortality data similarly. Residence-time-weighted metrics did not fit well. Compared with previous analyses based on the whole cohort of Libby workers hired after 1935, when job histories were less well-known and exposures less frequently measured (47% coverage), our analyses based on higher quality exposure data yielded an effect size as much as 3.6 times higher. Future occupational cohort studies should continue to refine retrospective exposure assessment methods, consider multiple exposure metrics, and explore new methods of maintaining statistical power while minimizing exposure measurement error.
Keywords
asbestos; exposure assessment; exposure modeling; Libby MT; lung cancer; vermiculite
Tags
IRIS
•
Libby Amphibole Asbestos (Draft, 2011)
OPPT REs
•
OPPT_Asbestos, Part I: Chrysotile_C. Engineering
Total – title/abstract screening
On topic
Peer review
Primary source
•
OPPT_Asbestos, Part I: Chrysotile_D. Exposure
Total – title/abstract screening
Off topic
•
OPPT_Asbestos, Part I: Chrysotile_E. Fate
Total – title/abstract screening
Off topic
•
OPPT_Asbestos, Part I: Chrysotile_F. Human Health
Total – title/abstract screening
On topic
Peer review
Primary source
Other forms of asbestos
•
OPPT_Asbestos, Part I: Chrysotile_Supplemental Search
LitSearch: Sept 2020 (Undated)
ProQuest
PubMed
Toxline
WoS
Vermiculite
Legacy Uses
Health Outcomes
Additional Legacy Terms
Exposure
Additional Legacy Terms
Suggested Legacy References
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