Magnetic-composite-modified polycrystalline-silicon nanowire field-effect transistor for vascular endothelial growth factor detection and cancer diagnosis | Health & Environmental Research Online (HERO)

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Citation
Tags

HERO ID

2275308

Reference Type

Journal Article

Title

Magnetic-composite-modified polycrystalline-silicon nanowire field-effect transistor for vascular endothelial growth factor detection and cancer diagnosis

Author(s)

Chen, HC; Qiu, JT; Yang, FL; Liu, YC; Chen, MC; Tsai, RY; Yang, HW; Lin, CY; Lin, CC; Wu, TS; Tu, YM; Xiao, MC; Ho, CH; Huang, CC; Lai, CS; Hua, MY

Year

2014

Is Peer Reviewed?

Yes

Journal

Analytical Chemistry
ISSN: 0003-2700
EISSN: 1520-6882

Volume

Issue

Page Numbers

9443-9450

Language

English

PMID

24641163

DOI

10.1021/ac5001898

Web of Science Id

WOS:000343017100018

URL

http://://WOS:000343017100018
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Abstract

This study proposes a vascular endothelial growth factor (VEGF) biosensor for diagnosing various stages of cervical carcinoma. In addition, the VEGF concentrations at various stages of cancer therapy are determined and compared to data obtained using computed tomography (CT) and cancer antigen 125 (CA-125). The increase in VEGF concentrations during operations offers useful insight into dosage timing during cancer therapy. This biosensor uses Avastin as the biorecognition element for the potential cancer biomarker VEGF and is based on a n-type polycrystalline silicon nanowire field-effect transistor (poly-SiNW-FET). Magnetic nanoparticles with poly[aniline-co-N-(1-one-butyric acid) aniline]-Fe3O4 (SPAnH-Fe3O4) shell-core structures are used as carriers for the Avastin loading and provide rapid purification due to their magnetic properties, which prevent the loss of bioactivity; furthermore, the high surface area of these structures increases the quantity of Avastin immobilized. The average concentrations in human blood for species that interfere with the detection specificity are also evaluated. The detection range of the biosensor for serum samples covers the results expected from both healthy individuals and cancer patients.

Keywords

article; aniline; antigens; bioactive properties; biomarkers; biosensors; blood serum; computed tomography; magnetic properties; nanoparticles; nanowires; patients; silicon; surface area; therapeutics; uterine cervical neoplasms; vascular endothelial growth factors