Jump to main content
US EPA
United States Environmental Protection Agency
Search
Search
Main menu
Environmental Topics
Laws & Regulations
About EPA
Health & Environmental Research Online (HERO)
Contact Us
Print
Feedback
Export to File
Search:
This record has one attached file:
Add More Files
Attach File(s):
Display Name for File*:
Save
Citation
Tags
HERO ID
2278047
Reference Type
Journal Article
Title
Ethnic characterization of a population of children exposed to high doses of arsenic via drinking water and a possible correlation with metabolic processes
Author(s)
Bobillo, C; Navoni, JA; Olmos, V; Merini, LJ; Villaamil Lepori, E; Corach, D
Year
2014
Volume
5
Issue
1
Page Numbers
1-10
Language
English
PMID
24596592
Abstract
Because the ratio between the two major arsenic metabolites is related to the adverse health effects of arsenic, numerous studies have been performed to establish a relationship between the ability to metabolically detoxify arsenic and other variables, including exposure level, gender, age and ethnicity. Because ethnicity may play a key role and provide relevant information for heterogeneous populations, we characterized a group of 70 children from rural schools in the Argentinean provinces of Chaco and Santiago del Estero who were exposed to high levels of arsenic. We used genetic markers for maternal, paternal and bi-parental ancestry to achieve this goal. Our results demonstrate that the Amerindian maternal linages are present in 100% of the samples, whereas the Amerindian component transmitted through the paternal line is less than 10%. Informative markers for autosomal ancestry show a predominantly European ancestry, in which 37% of the samples contained between 90 and 99% European ancestry. The native American component ranged from 50 to 80% in 15.7% of the samples, and in all but four samples, the African component was less than 10%. Correlation analysis demonstrated that the ethnicity and the ratio of the excreted arsenic metabolites monomethyl arsenic and dimethyl arsenic are not associated, dismissing a relationship between ethnic origin and differential metabolism.
Tags
IRIS
•
Arsenic Hazard ID
PubMed
Considered New
ToxNet
Considered New
ToxNet
Excluded
Toxnet Duplicates
2. Lit Search Updates through Oct 2015
PubMed
ToxNet
Considered
7. Other Studies through Oct 2015
Susceptibility
Not Relevant
Susceptibility Category
Genetic Polymorphisms
Health Effect Category
Not Relevant
•
Arsenic (Inorganic)
1. Literature
Lit search updates through Oct 2015
3. Hazard ID Screening
Other potentially supporting studies
5. Susceptibility Screening
Relevant
Human
•
Arsenic Susceptibility
4. Susceptibility and Lifestages
Genetic polymorphisms
5. Health Effect
Not Relevant
1. Susceptibility Literature Screening
Keyword Search
Health Effect Screening: Susceptibility
Home
Learn about HERO
Using HERO
Search HERO
Projects in HERO
Risk Assessment
Transparency & Integrity