Jump to main content
US EPA
United States Environmental Protection Agency
Search
Search
Main menu
Environmental Topics
Laws & Regulations
About EPA
Health & Environmental Research Online (HERO)
Contact Us
Print
Feedback
Export to File
Search:
This record has one attached file:
Add More Files
Attach File(s):
Display Name for File*:
Save
Citation
Tags
HERO ID
2278838
Reference Type
Journal Article
Title
Prenatal screening for clubfoot: what factors predict prenatal detection?
Author(s)
Mahan, ST; Yazdy, MM; Kasser, JR; Werler, MM
Year
2014
Is Peer Reviewed?
1
Journal
Prenatal Diagnosis
ISSN:
0197-3851
EISSN:
1097-0223
Volume
34
Issue
4
Page Numbers
389-393
Language
English
PMID
24395154
DOI
10.1002/pd.4320
URL
http://doi.wiley.com/10.1002/pd.4320
Exit
Abstract
OBJECTIVE:
Routine prenatal ultrasound has often resulted in the early detection of musculoskeletal disorders. The purpose of this study was to determine which socioeconomic factors are associated with prenatal detection of clubfoot.
METHODS:
The Slone Epidemiology Center at Boston University identified infants in three states (Massachusetts, New York, and North Carolina) who were reported as having a clubfoot. Mothers of these children were contacted and interviewed, and medical records obtained. Data were analyzed by using logistic regression to estimate odds ratios (ORs) and 95% confidence intervals (CIs).
RESULTS:
Overall detection of the clubfoot prenatally was 62.3% (421/676) but this varied considerably by state, 81.1% in Massachusetts (154/190), 58.5% in New York (124/212), and 52.2% in North Carolina (143/274). Multivariate analysis revealed that the strongest predictors for prenatal detection were maternal age ≥35 years (OR: 3.54), non-Hispanic black race (OR: 0.49), the presence of another birth defect (OR: 2.61), residing in Massachusetts (OR: 2.64), and the presence of a bilateral clubfoot (OR: 1.90).
CONCLUSIONS:
We found a statistically significantly higher rate of prenatal detection of clubfoot in Massachusetts and lower rate in younger mothers (age <35) and black mothers, even after adjustment for other sociodemographic variables. © 2014 John Wiley & Sons, Ltd.
Tags
IRIS
•
Arsenic Hazard ID
PubMed
Excluded
Non Peer Reviewed
PubMed
Excluded
Non Peer Reviewed
2. Lit Search Updates through Oct 2015
PubMed
Initial Filter
Non Peer Reviewed
•
Arsenic (Inorganic)
1. Literature
Lit search updates through Oct 2015
2. Initial Filter
Non peer-reviewed
Home
Learn about HERO
Using HERO
Search HERO
Projects in HERO
Risk Assessment
Transparency & Integrity