High fat diet aggravates arsenic induced oxidative stress in rat heart and liver
Dutta, M; Ghosh, D; Ghosh, AK; Bose, G; Chattopadhyay, A; Rudra, S; Dey, M; Bandyopadhyay, A; Pattari, SK; Mallick, S; Bandyopadhyay, D
HERO ID
2279308
Reference Type
Journal Article
Year
2014
Language
English
PMID
| HERO ID | 2279308 |
|---|---|
| In Press | No |
| Year | 2014 |
| Title | High fat diet aggravates arsenic induced oxidative stress in rat heart and liver |
| Authors | Dutta, M; Ghosh, D; Ghosh, AK; Bose, G; Chattopadhyay, A; Rudra, S; Dey, M; Bandyopadhyay, A; Pattari, SK; Mallick, S; Bandyopadhyay, D |
| Journal | Food and Chemical Toxicology |
| Volume | 66 |
| Issue | Elsevier |
| Page Numbers | 262-277 |
| Abstract | Arsenic is a well known global groundwater contaminant. Exposure of human body to arsenic causes various hazardous effects via oxidative stress. Nutrition is an important susceptible factor which can affect arsenic toxicity by several plausible mechanisms. Development of modern civilization led to alteration in the lifestyle as well as food habits of the people both in urban and rural areas which led to increased use of junk food containing high level of fat. The present study was aimed at investigating the effect of high fat diet on heart and liver tissues of rats when they were co-treated with arsenic. This study was established by elucidating heart weight to body weight ratio as well as analysis of the various functional markers, oxidative stress biomarkers and also the activity of the antioxidant enzymes. Histological analysis confirmed the biochemical investigations. From this study it can be concluded that high fat diet increased arsenic induced oxidative stress. |
| Doi | 10.1016/j.fct.2014.01.050 |
| Pmid | 24508525 |
| Wosid | WOS:000334139800032 |
| Url | https://linkinghub.elsevier.com/retrieve/pii/S0278691514000647 |
| Is Certified Translation | No |
| Dupe Override | No |
| Is Public | Yes |
| Language Text | English |
| Keyword | Arsenic; Oxidative stress; High fat diet; Heart damage; Liver damage |