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2279308 
Journal Article 
High fat diet aggravates arsenic induced oxidative stress in rat heart and liver 
Dutta, M; Ghosh, D; Ghosh, AK; Bose, G; Chattopadhyay, A; Rudra, S; Dey, M; Bandyopadhyay, A; Pattari, SK; Mallick, S; Bandyopadhyay, D 
2014 
Yes 
Food and Chemical Toxicology
ISSN: 0278-6915
EISSN: 1873-6351 
66 
262-277 
English 
Arsenic is a well known global groundwater contaminant. Exposure of human body to arsenic causes various hazardous effects via oxidative stress. Nutrition is an important susceptible factor which can affect arsenic toxicity by several plausible mechanisms. Development of modern civilization led to alteration in the lifestyle as well as food habits of the people both in urban and rural areas which led to increased use of junk food containing high level of fat. The present study was aimed at investigating the effect of high fat diet on heart and liver tissues of rats when they were co-treated with arsenic. This study was established by elucidating heart weight to body weight ratio as well as analysis of the various functional markers, oxidative stress biomarkers and also the activity of the antioxidant enzymes. Histological analysis confirmed the biochemical investigations. From this study it can be concluded that high fat diet increased arsenic induced oxidative stress. 
Arsenic; Oxidative stress; High fat diet; Heart damage; Liver damage 
• Arsenic Hazard ID
          PubMed
          Considered New
          PubMed
          Considered New
          PubMed
          ToxNet
          Considered New
          WOS
          ToxNet
          Excluded
               Toxnet Duplicates
          WOS
          ToxNet
          Excluded
               Toxnet Duplicates
               WOS Duplicates
          WOS
          ToxNet
          Excluded
               Toxnet Duplicates
               WOS Duplicates
     2. Lit Search Updates through Oct 2015
          PubMed
          WOS
          ToxNet
          Considered
     7. Other Studies through Oct 2015
          MOA
          Susceptibility
          Not Relevant
          Susceptibility Category
               Nutritional Deficiencies (includes socioeconomic status & BMI)
          Health Effect Category
               Cardiovascular disease
               Liver effects
• Arsenic (Inorganic)
     1. Literature
          Lit search updates through Oct 2015
     3. Hazard ID Screening
          Other potentially supporting studies
     4. Adverse Outcome Pathways/Networks Screening
          Relevant
     5. Susceptibility Screening
          Relevant
               Animal
          Excluded/Not relevant
• Arsenic MOA
     4. Adverse Outcome Pathways
          Oxidative stress related effects (includes non-specific SH reactions)
     5. Health Effect
          Cardiovascular disease
          Liver Effects
     1. MOA Literature Screening
          Susceptibility Screening
• Arsenic Susceptibility
     4. Susceptibility and Lifestages
          Nutritional deficiencies (includes socioeconomic status and BMI)
     5. Health Effect
          Cardiovascular disease
          Liver Effects
     1. Susceptibility Literature Screening
          Keyword Search
          Health Effect Screening: Susceptibility
     2. Excluded
          MOA/Mechanistic