Health & Environmental Research Online (HERO)


Print Feedback Export to File
2279453 
Journal Article 
Review 
Neurobehavioural effects of developmental toxicity 
Grandjean, P; Landrigan, PJ 
2014 
Yes 
The Lancet Neurology
ISSN: 1474-4422
EISSN: 1474-4465 
13 
330-338 
English 
Neurodevelopmental disabilities, including autism, attention-deficit hyperactivity disorder, dyslexia, and other cognitive impairments, affect millions of children worldwide, and some diagnoses seem to be increasing in frequency. Industrial chemicals that injure the developing brain are among the known causes for this rise in prevalence. In 2006, we did a systematic review and identified five industrial chemicals as developmental neurotoxicants: lead, methylmercury, polychlorinated biphenyls, arsenic, and toluene. Since 2006, epidemiological studies have documented six additional developmental neurotoxicants-manganese, fluoride, chlorpyrifos, dichlorodiphenyltrichloroethane, tetrachloroethylene, and the polybrominated diphenyl ethers. We postulate that even more neurotoxicants remain undiscovered. To control the pandemic of developmental neurotoxicity, we propose a global prevention strategy. Untested chemicals should not be presumed to be safe to brain development, and chemicals in existing use and all new chemicals must therefore be tested for developmental neurotoxicity. To coordinate these efforts and to accelerate translation of science into prevention, we propose the urgent formation of a new international clearinghouse. 
IRIS
• Arsenic Hazard ID
          PubMed
          Excluded
               Reviews
          PubMed
          Excluded
               Reviews
          WOS
          ToxNet
          Excluded
               Reviews
          ToxNet
          Excluded
               Reviews
               Toxnet Duplicates
          WOS
          ToxNet
          Excluded
               Reviews
               Toxnet Duplicates
               WOS Duplicates
          WOS
          ToxNet
          Excluded
               Reviews
               Toxnet Duplicates
               WOS Duplicates
     2. Lit Search Updates through Oct 2015
          PubMed
          WOS
          ToxNet
          Initial Filter
               Reviews
• Arsenic (Inorganic)
     1. Literature
          Lit search updates through Oct 2015
• Arsenic Susceptibility
     1. Susceptibility Literature Screening
          Keyword Search
     2. Excluded
          Not Relevant
• Methylmercury
     Literature Search: Jan 1998 - March 2017
          Human Data
          PubMed
          Science Direct
          ToxNet
          Web of Science
     Text Review: October 2019
          Considered Supplemental
• PCBs
     Litsearches
          Initial Filter
               Reviews
          LitSearch August 2015
               Pubmed
               Toxline
               WoS
     Targeted review search
          Source
• Phthalates – Targeted Search for Epidemiological Studies
     Excluded
     Source - August 2017 Update (Private)
          WOS - Forward Search Results
• Trimethylbenzenes (Interagency Science Discussion Draft)
     Literature Search for Related Compounds
          Cited
          Considered
     Cited August 2016
          Cited Toxicological Review
NAAQS
• ISA-Lead (2013 Final Project Page)
     Provisionally considered