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HERO ID
2283529
Reference Type
Journal Article
Title
Vertical mother-neonate transfer of maternal gut bacteria via breastfeeding
Author(s)
Jost, T; Lacroix, C; Braegger, CP; Rochat, F; Chassard, C
Year
2014
Is Peer Reviewed?
Yes
Journal
Environmental Microbiology
ISSN:
1462-2912
EISSN:
1462-2920
Volume
16
Issue
9
Page Numbers
2891-2904
Language
English
PMID
24033881
DOI
10.1111/1462-2920.12238
Abstract
Breast milk has recently been recognized as source of commensal and potential probiotic bacteria. The present study investigated whether viable strains of gut-associated obligate anaerobes are shared between the maternal and neonatal gut ecosystem via breastfeeding. Maternal faeces, breast milk and corresponding neonatal faeces collected from seven mothers-neonate pairs at three neonatal sampling points were analyzed by culture-independent (pyrosequencing) and culture-dependent methods (16S rRNA gene sequencing, pulsed field gel electrophoresis, random amplified polymorphic DNA and repetitive extragenic palindromic polymerase chain reaction. Pyrosequencing allowed identifying gut-associated obligate anaerobic genera, like Bifidobacterium, Bacteroides, Parabacteroides and members of the Clostridia (Blautia, Clostridium, Collinsella and Veillonella) shared between maternal faeces, breast milk and neonatal faeces. Using culture, a viable strain of Bifidobacterium breve was shown to be shared between all three ecosystems within one mother-neonate pair. Furthermore, pyrosequencing revealed that several butyrate-producing members of the Clostridia (Coprococcus, Faecalibacterium, Roseburia and Subdoligranulum) were shared between maternal faeces and breast milk. This study shows that (viable) obligate gut-associated anaerobes may be vertically transferred from mother to neonate via breastfeeding. Thus, our data support the recently suggested hypothesis of a novel way of mother-neonate communication, in which maternal gut bacteria reach breast milk via an entero-mammary pathway to influence neonatal gut colonization and maturation of the immune system.
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n-Butanol
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Pubmed
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Pubmed - 3/2014
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Not chemical specific
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